A general theory for temperature dependence in biology

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dc.contributor.authorArroyoa, Jose Ignacio
dc.contributor.authorDiez, Beatriz
dc.contributor.authorKempes, Christopher P.
dc.contributor.authorWest, Geoffrey B.
dc.contributor.authorMarquet, Pablo A.
dc.date.accessioned2025-01-20T20:22:59Z
dc.date.available2025-01-20T20:22:59Z
dc.date.issued2022
dc.description.abstractAt present, there is no simple, first principles-based, and general model for quantitatively describing the full range of observed biological temperature responses. Here we derive a general theory for temperature dependence in biology based on Eyring-EvansPolanyi's theory for chemical reaction rates. Assuming only that the conformational entropy of molecules changes with temperature, we derive a theory for the temperature dependence of enzyme reaction rates which takes the form of an exponential function modified by a power law and that describes the characteristic asymmetric curved temperature response. Based on a few additional principles, our model can be used to predict the temperature response above the enzyme level, thus spanning quantum to classical scales. Our theory provides an analytical description for the shape of temperature response curves and demonstrates its generality by showing the convergence of all temperature dependence responses onto universal relationships-a universal data collapse-under appropriate normalization and by identifying a general optimal temperature, around 25.C, characterizing all temperature response curves. The model provides a good fit to empirical data for a wide variety of biological rates, times, and steady-state quantities, from molecular to ecological scales and across multiple taxonomic groups (from viruses to mammals). This theory provides a simple framework to understand and predict the impact of temperature on biological quantities based on the first principles of thermodynamics, bridging quantum to classical scales.
dc.fuente.origenWOS
dc.identifier.doi10.1073/pnas.2119872119
dc.identifier.eissn1091-6490
dc.identifier.issn0027-8424
dc.identifier.urihttps://doi.org/10.1073/pnas.2119872119
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92703
dc.identifier.wosidWOS:000987690300012
dc.issue.numero30
dc.language.isoen
dc.revistaProceedings of the national academy of sciences of the united states of america
dc.rightsacceso restringido
dc.subjecttemperature kinetics
dc.subjectscaling
dc.subjectmetabolic theory
dc.subject.ods13 Climate Action
dc.subject.odspa13 Acción por el clima
dc.titleA general theory for temperature dependence in biology
dc.typeartículo
dc.volumen119
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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