PaCO2 and Neurodevelopment in Extremely Low Birth Weight Infants

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dc.contributor.authorMcKee, Lara A.
dc.contributor.authorFabres, Jorge
dc.contributor.authorHoward, George
dc.contributor.authorPeralta Carcelen, Myriam
dc.contributor.authorCarlo, Waldemar A.
dc.contributor.authorAmbalavanan, Namasivayam
dc.date.accessioned2024-01-10T12:07:20Z
dc.date.available2024-01-10T12:07:20Z
dc.date.issued2009
dc.description.abstractObjective To determine the relationship between PaCO2 in the first 4 days of life and neurodevelopment at 18 to 22 months.
dc.description.abstractStudy design Stepwise regression and exhaustive CHAID (Chi-squared Automatic Interaction Detector) analyses were done for neurodevelopmental impairment (NDI), mental developmental index (MDI), and psychomotor developmental index (PDI) using clinical variables in combination with the maximum (max), time-weighted average (avg), and max-minimum (max-min) PaCO2 in 400 infants of 401 to 1000 g birth weight (BW).
dc.description.abstractResults By regression, NDI predictors were male sex, non-Caucasian race, premature prolonged rupture of membranes (PPROM), lower BW, IVH 3 to 4, and lower 1-minute Apgar score. For lower MDI, predictors were male sex, non-Caucasian race, PPROM, IVH 3 to 4, sepsis, and higher max-min PaCO2. For lower PDI, predictors were male sex, PPROM, lower BW, IVH 3 to 4, sepsis, and higher avg PaCO2. By CHAID, the most important predictor of NDI was sex. For MDI, sex was most important followed by max-min PaCO2>42 mm Hg in boys. For PDI, IVH was most important, followed by max-min PaCO2>42 mm Hg for grade <= 2 IVH.
dc.description.abstractConclusions Extreme fluctuations in PaCO2 and higher max PaCO2 are associated with worse neurodevelopmental outcomes and may indicate either a greater severity of illness or contribution of PaCO2 to pathophysiology of adverse neurodevelopment. (J Pediatr 2009; 155:217-21).
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jpeds.2009.02.024
dc.identifier.eissn1097-6833
dc.identifier.issn0022-3476
dc.identifier.pubmedidMEDLINE:19447409
dc.identifier.urihttps://doi.org/10.1016/j.jpeds.2009.02.024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76272
dc.identifier.wosidWOS:000268781200016
dc.information.autorucMedicina;Fabres J;S/I;71713
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final221
dc.pagina.inicio217
dc.publisherMOSBY-ELSEVIER
dc.revistaJOURNAL OF PEDIATRICS
dc.rightsacceso restringido
dc.subjectSEVERE INTRAVENTRICULAR HEMORRHAGE
dc.subjectPRETERM INFANTS
dc.subjectBRONCHOPULMONARY DYSPLASIA
dc.subjectHYPERCAPNIA
dc.subjectCHILDREN
dc.subjectLIFE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePaCO2 and Neurodevelopment in Extremely Low Birth Weight Infants
dc.typeartículo
dc.volumen155
sipa.codpersvinculados71713
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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