EFFECTS OF EXTRACORPOREAL-CIRCULATION ON RENAL-FUNCTION IN CORONARY SURGICAL PATIENTS

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dc.contributor.authorLEMA, G
dc.contributor.authorMENESES, G
dc.contributor.authorURZUA, J
dc.contributor.authorJALIL, R
dc.contributor.authorCANESSA, R
dc.contributor.authorMORAN, S
dc.contributor.authorIRARRAZAVAL, MJ
dc.contributor.authorZALAQUETT, R
dc.contributor.authorORELLANA, P
dc.date.accessioned2024-01-10T12:38:35Z
dc.date.available2024-01-10T12:38:35Z
dc.date.issued1995
dc.description.abstractWe prospectively studied perioperative changes of renal function in 12 previously normal patients (plasma creatinine <1.5 mg/dL) scheduled for elective coronary surgery. Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured with inulin and I-125-hippuran clearances before induction of anesthesia, before cardiopulmonary bypass (CPB), during hypo- and normothermic CPB, after sternal closure, and 1 h postoperatively. Renal and systemic vascular resistances were calculated. Urinary N-acetyl-beta-D-glucosaminidase (NAG) and plasma and urine electrolytes were measured, and free water, osmolal, and (creatinine clearances, and fractional excretion of sodium and potassium were calculated before and after surgery. I-125-hippuran clearance was lower than normal in all patients before surgery. During hypothermic CPB, ERPF increased significantly (from 261 +/- 107 to 413 +/- 261 mL/min) and returned toward baseline values during normothermia. GFR was normal before and after surgery and decreased nonsignificantly during CPB. Filtration fraction was above normal before surgery and decreased significantly during CPB (038 +/- 0.09 to 0.18 +/- 0.06). Renal vascular resistance (RVR) was high before surgery and further increased after sternotomy (from 18,086 +/- 6849 to 30,070 +/- 24,427 dynes . s . cm(-5)), decreasing during CPB to 13,9647 +/- 14,662 dynes . s . cm(-5). Urine NAG, creatinine, and free water clearances were normal in all patients both pre- and postoperatively. Osmolal clearance and fractional excretion of sodium increased postoperatively from 1.54 +/- 0.06 to 12.47 +/- 11.37 mL/min, and from 0.44 +/- 0.3 to 6.07 +/- 6.27, respectively. We conclude that renal function does not seem to be adversely affected by CPB. Significant functional alterations, such as decreased ERPF and increased RVR, were found before and during surgery, preceding CPB. These periods could contribute to postoperative renal dysfunction.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00000539-199509000-00003
dc.identifier.issn0003-2999
dc.identifier.pubmedidMEDLINE:7653802
dc.identifier.urihttps://doi.org/10.1097/00000539-199509000-00003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77068
dc.identifier.wosidWOS:A1995RR78000003
dc.information.autorucMedicina;Canessa R;S/I;55800
dc.information.autorucMedicina;Irarrázaval M;S/I;98706
dc.information.autorucActividades Universitarias;Jalil R;S/I;57165
dc.information.autorucMedicina;Lema G;S/I;99835
dc.information.autorucMedicina;Morán S;S/I;98562
dc.information.autorucMedicina;Orellana C;S/I;100057
dc.information.autorucMedicina;Urzúa J;S/I;98495
dc.information.autorucMedicina;Zalaquett R;S/I;100042
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final451
dc.pagina.inicio446
dc.publisherWILLIAMS & WILKINS
dc.revistaANESTHESIA AND ANALGESIA
dc.rightsacceso restringido
dc.subjectCARDIOPULMONARY BYPASS
dc.subjectBLOOD-FLOW
dc.subjectDYSFUNCTION
dc.subjectPERFUSION
dc.subjectCLEARANCE
dc.subjectPRESSURE
dc.subjectSURGERY
dc.subjectFAILURE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECTS OF EXTRACORPOREAL-CIRCULATION ON RENAL-FUNCTION IN CORONARY SURGICAL PATIENTS
dc.typeartículo
dc.volumen81
sipa.codpersvinculados55800
sipa.codpersvinculados98706
sipa.codpersvinculados57165
sipa.codpersvinculados99835
sipa.codpersvinculados98562
sipa.codpersvinculados100057
sipa.codpersvinculados98495
sipa.codpersvinculados100042
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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