Hypotonia of the newborn or infant

Simple item page
dc.contributor.authorAlarcon Benitez, Daniela
dc.contributor.authorBeytia Reyes, Maria De los Angeles
dc.contributor.authorEscobar, Raul G.
dc.contributor.authorNunez Farias, Alicia
dc.contributor.authorLopez Bohner, Maria Eugenia
dc.contributor.authorAvila-Smirnow, Daniela
dc.date.accessioned2025-01-20T21:02:50Z
dc.date.available2025-01-20T21:02:50Z
dc.date.issued2022
dc.description.abstractHypotonia of the newborn or infant is defined as decreased resistance to passive movement and is a frequent diagnostic challenge in pediatric practice. The hypotonic syndrome is a working diagnosis and its etiology must be identified to determine associated morbidities, prognosis, and management. Rapid advances in bioinformatics and molecular genetic testing allow for early accurate diagnoses in the diagnostic process. Therefore, it is necessary to carry out an updated review on this topic. The objective of this non-systematic narrative review is to describe the diagnostic approach to hypotonic syndrome and its main etiologies. A review of the literature from PubMed and Scielo databases was carried out, including relevant articles in English and Spanish published in the last 15 years. We emphasize the value of the clinical examination and history in locating the cause of hypotonia (cen-tral or peripheral) as the first step toward the etiological diagnosis. Systemic diseases such as sepsis, hypoxic-ischemic encephalopathy, heart failure, and metabolic and electrolyte abnormalities are still common causes of central hypotonia. Peripheral hypotonia involves disorders of the anterior horn of the spinal cord, peripheral nerve, neuromuscular junction and muscle, of inherited and acquired origin. The use of images of the central nervous system and muscle and genetic panels and exome, constitute the most recent contributions to the diagnosis of hypotonic syndrome. This article propo-ses an initial approach based on the main clinical clues leading to a certain diagnosis. Its therapy is supportive, except for some conditions that require specific treatment.
dc.fuente.origenWOS
dc.identifier.doi10.32641/andespediatr.v93i4.4050
dc.identifier.eissn2452-6053
dc.identifier.urihttps://doi.org/10.32641/andespediatr.v93i4.4050
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93089
dc.identifier.wosidWOS:000848308600002
dc.issue.numero4
dc.language.isoen
dc.pagina.final469
dc.pagina.inicio458
dc.revistaAndes pediatrica
dc.rightsacceso restringido
dc.subjectMuscle Hypotonia
dc.subjectNeonatal Hypotonia
dc.subjectSpinal Muscular Atrophy
dc.subjectMyopathies
dc.subjectCreatine Kinase
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHypotonia of the newborn or infant
dc.typeartículo
dc.volumen93
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas