How force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen

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dc.catalogadorgjm
dc.contributor.authorInostroza, Carla
dc.contributor.authorBerríos, Pablo
dc.contributor.authorOrellana, Ivana
dc.contributor.authorRivas-Pardo, Jaime Andrés
dc.contributor.authorAguayo Paul, Sebastián
dc.date.accessioned2025-11-21T12:47:57Z
dc.date.available2025-11-21T12:47:57Z
dc.date.issued2025
dc.description.abstractStreptococcus mutans is a caries-associated bacterium with the ability to adhere to the surface of oral tissues and promote biofilm formation. For this purpose, S. mutans expresses a range of specialized surface adhesins, among which collagen-binding proteins (CBPs) have demonstrated an important function regarding attachment to dentin, bacterial coaggregation, and extracellular matrix invasion. Understanding the mechanobiological behavior of CBPs, particularly their interaction with collagens during the process of bacterial adhesion, is crucial for developing novel strategies to prevent biofilm formation in oral and remote tissues. Therefore, this review summarizes recent evidence regarding the main mechanical properties of the relevant S. mutans CBPs SpaP, WapA, Cnm, and Cbm, and how their mechanobiological and adhesive characteristics play an important role in their virulence toward the host. Particularly, we will focus on how state-of-the-art interdisciplinary approaches such as atomic force microscopy (AFM)-based single-molecule force spectroscopy (SMFS) and single-cell force spectroscopy (SCFS) have been employed to characterize S. mutans and CBP attachment to collagen substrates and mechanical behavior in real-time and under physiological conditions. Altogether, the potential use of AFM SMFS and SCFS to explore novel anti-biofilm molecules against S. mutans remains an exciting possibility for the development of caries-preventive treatments in the future.
dc.format.extent17 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1080/1040841X.2025.2584074
dc.identifier.urihttps://doi.org/10.1080/1040841X.2025.2584074
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107072
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Aguayo Paul, Sebastián; 0000-0003-0900-1993; 1062336
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaCritical Reviews in Microbiology
dc.rightsacceso restringido
dc.subjectAtomic force microscopy
dc.subjectBacterial adhesion
dc.subjectStreptococcus mutans
dc.subjectBiophysicsoral biofilm
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow force drives pathogenicity: mechanoregulation of Streptococcus mutans adhesion to collagen
dc.typeartículo
sipa.codpersvinculados1062336
sipa.trazabilidadORCID;2025-11-17
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