Hormone receptor-positive early breast cancer in young women: A comprehensive review

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dc.article.number102804
dc.catalogadorgjm
dc.contributor.authorWalbaum García, Benjamín Vicente
dc.contributor.authorGarcía-Fructuoso, Isabel
dc.contributor.authorMartínez-Sáez, Olga
dc.contributor.authorSchettini, Francesco
dc.contributor.authorSánchez Rojel, César Giovanni
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorChic, Nuria
dc.contributor.authorMuñoz-Carrillo, Javier
dc.contributor.authorAdamo, Barbara
dc.contributor.authorMuñoz, Montserrat
dc.contributor.authorPartridge, Ann H.
dc.contributor.authorBellet, Meritxell
dc.contributor.authorBrasó-Maristany, Fara
dc.contributor.authorPrat, Aleix
dc.contributor.authorVidal Losada, Maria
dc.date.accessioned2024-07-19T17:18:38Z
dc.date.available2024-07-19T17:18:38Z
dc.date.issued2024
dc.description.abstractThe incidence of breast cancer in ≤ 40 yr-old women (YWBC) has been steadily increasing in recent decades. Although this group of patients represents less than 10 % of all newly diagnosed BC cases it encompasses a significant burden of disease. Usually underrepresented in clinical trials, YWBCs are also characterized by late diagnoses and poorly differentiated, aggressive-subtype disease, partly explaining its poor prognosis along with a high recurrence risk, and high mortality rates. On the other hand, YWBC treatment poses unique challenges such as preservation of fertility, and long-term toxicity and adverse events. Herein, we summarize the current evidence in hormone receptor-positive YWBC including specific risk factors, clinicopathologic and genomic features, and available evidence on response to chemotherapy and endocrine therapy. Overall, we advocate for a more comprehensive multidisciplinary healthcare model to improve the outcomes and the quality of life of this subset of younger patients.
dc.fechaingreso.objetodigital2024-08-30
dc.format.extent31 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.ctrv.2024.102804
dc.identifier.urihttps://doi.org/10.1016/j.ctrv.2024.102804
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87179
dc.identifier.wosidWOS:001285570600001
dc.information.autorucEscuela de Medicina; Walbaum García, Benjamín Vicente; 0000-0003-2314-5360; 163702
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaCancer Treatment Reviews
dc.rightsacceso restringido
dc.subjectYoung women
dc.subjectEarly breast cancer
dc.subjectHormone receptor-positive
dc.subjectBiomarkers
dc.subjectPrognosis
dc.subjectGenomic-signatures
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHormone receptor-positive early breast cancer in young women: A comprehensive review
dc.typepreprint
sipa.codpersvinculados163702
sipa.codpersvinculados135644
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-07-15
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