Historia natural de retinopatía diabética en un estudio a largo plazo en pacientes con diabetes tipo 1. Factores de riesgo para progresión a enfermedad proliferante

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dc.article.number02
dc.catalogadorpva
dc.contributor.authorVerdaguer, J.
dc.contributor.authorZanolli, M.
dc.contributor.authorSepúlveda, G.
dc.contributor.authorGarcía de los Ríos, M.
dc.contributor.authorDomínguez, Angélica
dc.date.accessioned2024-03-04T15:19:43Z
dc.date.available2024-03-04T15:19:43Z
dc.date.issued2009
dc.description.abstractBackground: Diabetic retinopathy is one of the most common causes of blindness among adults. Aim: To report the natural history of diabetic retinopathy among Chilean patients with type 1 diabetes followed for a mean of 18 years. Material and methods: Retrospective review of medical records of 39 patients aged 26 to 70 years, (20 females, 78 eyes) with type 1 diabetes controlled by the same ophthalmologist from 1971 to 2008. A questionnaire was sent to each patient and their treating physician to request information about the evolution of the disease and metabolic control. Results: The questionnaire was answered by 24 patients (62%) and 21 attending physicians (54%). Small hard drusen were observed in 25 patients (64%). In 12 cases the drusen were detected before the development of any type of retinopathy. Eleven women became pregnant and retinopathy progressed in four of them. Twently three patients (59%) developed proliferative diabetic retinopathy (PDR). Patients with PDR had a significantly longer duration of diabetes and worse glycemic control. There was a higher frequency of diabetic nephropathy in the PDR group, but only 13 patients out of 23 with PDR had nephropathy. The retinopathy progressed to high risk PDR two years after successful kidney-pancreas transplantation in one patient. Conclusions. In patients with type 1 diabetes mellitus, small hard drusen may be the initial manifestation of diabetic retinopathy. Risk factors for progression to PDR were duration of diabetic and poor glycemic control. Nephropathy was more prevalent in patients with PDR, but a significant group of PDR patients did not have demonstrable nephropathy (RevMéd Chile 2009; 137:1145-52).
dc.fechaingreso.objetodigital2024-05-29
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872009000900002
dc.identifier.issn0034-9887
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-70450192557&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/82478
dc.information.autorucEscuela de Medicina; Dominguez De Landa, Maria Angelica; 0000-0001-7477-7574; 131798
dc.issue.numero9
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1152
dc.pagina.inicio1145
dc.revistaRevista médica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectDiabetes mellitus, type 1
dc.subjectDiabetic nephropathies
dc.subjectDiabetic retinopathy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHistoria natural de retinopatía diabética en un estudio a largo plazo en pacientes con diabetes tipo 1. Factores de riesgo para progresión a enfermedad proliferante
dc.title.alternativeHistoria natural de retinopatía diabética en un estudio a largo plazo en pacientes con diabetes tipo 1. Factores de riesgo para progresión a enfermedad proliferante
dc.typeartículo
dc.volumen137
sipa.codpersvinculados131798
sipa.trazabilidadORCID;2024-01-15
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