DEVELOPMENT OF TOLERANCE TO THE EXCITATORY EFFECT OF MORPHINE AND CROSS-TOLERANCE TO THE INHIBITORY-ACTION OF BETA-ENDORPHIN IN THE ISOLATED RAT VAS-DEFERENS

Simple item page
dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorMIRANDA, H
dc.contributor.authorHUIDOBRO, F
dc.date.accessioned2025-01-23T19:44:21Z
dc.date.available2025-01-23T19:44:21Z
dc.date.issued1981
dc.description.abstractIn the isolated rat vas deferens, morphine caused an increase in the neuromuscular twitch evoked by electrical stimulation. In rats chronically treated with morphine, the concentration of the opiate required to cause a 50% increase in the twitch was about 3 times larger than needed to elicit the same response in vasa from rats treated with a placebo. The simultaneous administration of naloxone plus morphine partially antagonized tolerance development by about 22%. Morphine tolerance was extended to other opiate-like alkaloids such as etonitazene and a derivative of azidomorphine (CAM). In contrast to the effects of morphine, .beta.-endorphin inhibited neuromuscular transmission. Vasa from rats chronically treated with morphine were about 10 times less sensitive to the inhibitory effect of .beta.-endorphin as compared to paired placebo-treated controls. Chronic naloxone treatment in conjunction with morphine significantly reduced the cross-opiate tolerance by 66%. Morphine may interact at 2 different sites in the nerve terminals of the rat vas deferens.
dc.fuente.origenWOS
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100015
dc.identifier.wosidWOS:A1981LB42800008
dc.issue.numero7
dc.language.isoen
dc.pagina.final779
dc.pagina.inicio773
dc.revistaLife sciences
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDEVELOPMENT OF TOLERANCE TO THE EXCITATORY EFFECT OF MORPHINE AND CROSS-TOLERANCE TO THE INHIBITORY-ACTION OF BETA-ENDORPHIN IN THE ISOLATED RAT VAS-DEFERENS
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas