INVOLVEMENT OF CALCIUM CHANNELS IN THE CONTRACTILE ACTIVITY OF NEUROTENSIN BUT NOT ACETYLCHOLINE - STUDIES WITH CALCIUM-CHANNEL BLOCKERS AND BAY-K8644 ON THE RAT FUNDUS

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dc.contributor.authorDONOSO, MV
dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorKULLAK, A
dc.date.accessioned2025-01-23T19:26:20Z
dc.date.available2025-01-23T19:26:20Z
dc.date.issued1986
dc.description.abstractThe contractile activity of neurotensin and acetylcholine on rat isolated fundus strips was examined in preparations maintained on Tyrode buffer containing 2.5, 1.0 or 0 mM Ca2+. While the neurotensin contractions depended markedly on the external Ca2+ concentration, the acetylcholine-induced muscular responses were not significantly affected by omission of calcium in the superfusion media. 2 Pre-incubation for at fundus strips with nifedipine (0.03-3.8 .mu.M), diltiazem (0.5-3.5 .mu.M) or methoxyverapamil (0.3-1.3 .mu.M) antagonized in a non-surmountable fashion the contractile activity of neurotensin but not of acetylcholine. 3 Pretreatment with Bay K 8644 potentiated in a concentration-dependent fashion the contractile activity of rat fundus strips to neurotensin without modifying to any significant degree the acetylcholine-induced contractions. 4 Nifedipine blocked in a concentration-dependent manner by Bay K 8644-induced potentiation of the neurotensin contractile responses in the fundus. 5 Results demonstrate the dependence on external calcium of the contractile activity of neurotensin and the resistance of the muscarinic response to external calcium manipulations. The coupling of the neurotensin receptor to calcium channels is discussed.
dc.fuente.origenWOS
dc.identifier.eissn1476-5381
dc.identifier.issn0007-1188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99597
dc.identifier.wosidWOS:A1986D585800014
dc.issue.numero4
dc.language.isoen
dc.pagina.final846
dc.pagina.inicio837
dc.revistaBritish journal of pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINVOLVEMENT OF CALCIUM CHANNELS IN THE CONTRACTILE ACTIVITY OF NEUROTENSIN BUT NOT ACETYLCHOLINE - STUDIES WITH CALCIUM-CHANNEL BLOCKERS AND BAY-K8644 ON THE RAT FUNDUS
dc.typeartículo
dc.volumen88
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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