Analysis of 4,164 type 1 diabetes antibody profiles in a chilean health centreMarcadores inmunológicos de diabetes tipo 1: Análisis de 4.164 perfiles en un centro de salud de Chile

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dc.article.number102546
dc.article.number102546
dc.contributor.authorVERA F.
dc.contributor.authorRODRÍGUEZ D.
dc.contributor.authorQUIROGA T.
dc.contributor.authorJOFRÉ P.
dc.contributor.authorGRASSI B.
dc.contributor.authorPOLLAK F.
dc.contributor.authorLAGOS R.
dc.date.accessioned2025-05-01T10:32:02Z
dc.date.available2025-05-01T10:32:02Z
dc.date.issued2021
dc.description.abstract© 2021 Sociedad Medica de Santiago. All rights reserved.Background: Previous studies have assessed the role of Type 1 diabetes (DM1) antibodies as predictors of the natural history of disease. Aim: To determine the frequency and combinations of positivity for DM1 antibodies in patients with DM1 and the relationship between antibody positivity and the age of the patient. To explore the relationship between history of insulin therapy or diabetic ketoacidosis (DKA) at the onset of the disease with antibody positivity in a subsample. Material and Methods: Data was gathered from every sample processed for DM1 antibodies in our laboratory between January 2015 and September 2019. Medical records from 84 patients who tested positive for at least one antibody were revised to study the relationship between insulin therapy or DKA at the onset of the disease with antibody positivity. Results: Forty percent of DM1 antibody tests were positive. Among positive tests, 1, 2, 3 or 4 DM1 antibodies were detected in 48%, 33%, 17% and 3% of cases, respectively. The likelihood of testing positive was inversely related with age for ICA, GAD, IA-2, ZnT8 and directly proportional for IAA (β = -0,012; -0,013; -0,014; -0,009; 0,005 respectively). An association between DKA at the onset of the disease and IA-2 positivity was observed (Odds ratio (OR) 5.38 95% confidence intervals (CI) 1.79 - 16.16, P < 0.01). No association was found between IAA positivity and history of insulin therapy (OR 2.25 95%CI 0.63 - 7.90, P = 0.2403). Conclusions: The results obtained from this study represent a novel local profile of DM1 antibody data, highlighting a relationship between antibody positivity and age.
dc.description.funderFONDECYT
dc.description.funderMarine Energy Research & Innovation Center
dc.format.extent15 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/s0034-98872021000300330
dc.identifier.eisbn978-84-9880-797-4
dc.identifier.eissn07176163
dc.identifier.isbn978-0-12-817240-7
dc.identifier.issn07176163 00349887
dc.identifier.pubmedid33361143
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85111569921
dc.identifier.urihttps://doi.org/10.4067/s0034-98872021000300330
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103811
dc.identifier.wosidWOS:000645754400001
dc.information.autorucEscuela de Medicina; Grassi Corrales Bruno; 0000-0003-0095-9740; 132804
dc.information.autorucEscuela de Medicina; Quiroga Gutierrez Sara Teresita; S/I; 52601
dc.information.autorucEscuela de Medicina; Pollak Cornejo Felipe Antonio; S/I; 100375
dc.issue.numero3515
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final338
dc.pagina.inicio330
dc.publisherAcademic Press
dc.relation.ispartof7th Workshop On Educational Innovation In Architecture (JIDA), NOV 14-15, 2019, Madrid, SPAIN
dc.revistaRevista Medica de Chile
dc.rightsAcceso abierto
dc.subjectAntibodies
dc.subjectDiabetes Mellitus
dc.subjectDiabetic Ketoacidosis
dc.subjectImmunoassay
dc.subjectInsulin Antibodies
dc.subjectType 1
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods02 Zero hunger
dc.subject.odspa02 Hambre cero
dc.titleAnalysis of 4,164 type 1 diabetes antibody profiles in a chilean health centreMarcadores inmunológicos de diabetes tipo 1: Análisis de 4.164 perfiles en un centro de salud de Chile
dc.typeartículo
dc.volumen149
sipa.codpersvinculados132804
sipa.codpersvinculados52601
sipa.codpersvinculados100375
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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