Analysis of 4,164 type 1 diabetes antibody profiles in a chilean health centreMarcadores inmunológicos de diabetes tipo 1: Análisis de 4.164 perfiles en un centro de salud de Chile
dc.article.number | 102546 | |
dc.article.number | 102546 | |
dc.contributor.author | VERA F. | |
dc.contributor.author | RODRÍGUEZ D. | |
dc.contributor.author | QUIROGA T. | |
dc.contributor.author | JOFRÉ P. | |
dc.contributor.author | GRASSI B. | |
dc.contributor.author | POLLAK F. | |
dc.contributor.author | LAGOS R. | |
dc.date.accessioned | 2025-05-01T10:32:02Z | |
dc.date.available | 2025-05-01T10:32:02Z | |
dc.date.issued | 2021 | |
dc.description.abstract | © 2021 Sociedad Medica de Santiago. All rights reserved.Background: Previous studies have assessed the role of Type 1 diabetes (DM1) antibodies as predictors of the natural history of disease. Aim: To determine the frequency and combinations of positivity for DM1 antibodies in patients with DM1 and the relationship between antibody positivity and the age of the patient. To explore the relationship between history of insulin therapy or diabetic ketoacidosis (DKA) at the onset of the disease with antibody positivity in a subsample. Material and Methods: Data was gathered from every sample processed for DM1 antibodies in our laboratory between January 2015 and September 2019. Medical records from 84 patients who tested positive for at least one antibody were revised to study the relationship between insulin therapy or DKA at the onset of the disease with antibody positivity. Results: Forty percent of DM1 antibody tests were positive. Among positive tests, 1, 2, 3 or 4 DM1 antibodies were detected in 48%, 33%, 17% and 3% of cases, respectively. The likelihood of testing positive was inversely related with age for ICA, GAD, IA-2, ZnT8 and directly proportional for IAA (β = -0,012; -0,013; -0,014; -0,009; 0,005 respectively). An association between DKA at the onset of the disease and IA-2 positivity was observed (Odds ratio (OR) 5.38 95% confidence intervals (CI) 1.79 - 16.16, P < 0.01). No association was found between IAA positivity and history of insulin therapy (OR 2.25 95%CI 0.63 - 7.90, P = 0.2403). Conclusions: The results obtained from this study represent a novel local profile of DM1 antibody data, highlighting a relationship between antibody positivity and age. | |
dc.description.funder | FONDECYT | |
dc.description.funder | Marine Energy Research & Innovation Center | |
dc.format.extent | 15 páginas | |
dc.fuente.origen | Scopus | |
dc.identifier.doi | 10.4067/s0034-98872021000300330 | |
dc.identifier.eisbn | 978-84-9880-797-4 | |
dc.identifier.eissn | 07176163 | |
dc.identifier.isbn | 978-0-12-817240-7 | |
dc.identifier.issn | 07176163 00349887 | |
dc.identifier.pubmedid | 33361143 | |
dc.identifier.scieloid | S0718-69242020000300109 | |
dc.identifier.scopusid | SCOPUS_ID:85111569921 | |
dc.identifier.uri | https://doi.org/10.4067/s0034-98872021000300330 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/103811 | |
dc.identifier.wosid | WOS:000645754400001 | |
dc.information.autoruc | Escuela de Medicina; Grassi Corrales Bruno; 0000-0003-0095-9740; 132804 | |
dc.information.autoruc | Escuela de Medicina; Quiroga Gutierrez Sara Teresita; S/I; 52601 | |
dc.information.autoruc | Escuela de Medicina; Pollak Cornejo Felipe Antonio; S/I; 100375 | |
dc.issue.numero | 3515 | |
dc.language.iso | es | |
dc.nota.acceso | Sin adjunto | |
dc.pagina.final | 338 | |
dc.pagina.inicio | 330 | |
dc.publisher | Academic Press | |
dc.relation.ispartof | 7th Workshop On Educational Innovation In Architecture (JIDA), NOV 14-15, 2019, Madrid, SPAIN | |
dc.revista | Revista Medica de Chile | |
dc.rights | Acceso abierto | |
dc.subject | Antibodies | |
dc.subject | Diabetes Mellitus | |
dc.subject | Diabetic Ketoacidosis | |
dc.subject | Immunoassay | |
dc.subject | Insulin Antibodies | |
dc.subject | Type 1 | |
dc.subject.ddc | 510 | |
dc.subject.dewey | Matemática física y química | es_ES |
dc.subject.ods | 02 Zero hunger | |
dc.subject.odspa | 02 Hambre cero | |
dc.title | Analysis of 4,164 type 1 diabetes antibody profiles in a chilean health centreMarcadores inmunológicos de diabetes tipo 1: Análisis de 4.164 perfiles en un centro de salud de Chile | |
dc.type | artículo | |
dc.volumen | 149 | |
sipa.codpersvinculados | 132804 | |
sipa.codpersvinculados | 52601 | |
sipa.codpersvinculados | 100375 | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga WOS-SCOPUS;01-05-2025 |