The 4E approach to the human microbiome: Nested interactions between the gut-brain/body system within natural and built environments

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dc.contributor.authorPalacios-Garcia, Ismael
dc.contributor.authorMhuireach, Gwynne A.
dc.contributor.authorGrasso-Cladera, Aitana
dc.contributor.authorCryan, John F.
dc.contributor.authorParada, Francisco J.
dc.date.accessioned2025-01-20T21:10:31Z
dc.date.available2025-01-20T21:10:31Z
dc.date.issued2022
dc.description.abstractThe complexity of the human mind and its interaction with the environment is one of the main epistemological debates throughout history. Recent ideas, framed as the 4E perspective to cognition, highlight that human experience depends causally on both cerebral and extracranial processes, but also is embedded in a particular sociomaterial context and is a product of historical accumulation of trajectory changes throughout life. Accordingly, the human microbiome is one of the most intriguing actors modulating brain function and physiology. Here, we present the 4E approach to the Human Microbiome for understanding mental processes from a broader perspective, encompassing one's body physiology and environment throughout their lifespan, interconnected by microbiome community structure and dynamics. We review evidence supporting the approach theoretically and motivates the study of the global set of microbial ecosystem networks encountered by a person across their lifetime (from skin to gut to natural and built environments). We furthermore trace future empirical implementation of the approach. We finally discuss novel research opportunities and clinical interventions aimed toward developing low-cost/high-benefit integrative and personalized bio-psycho-socio-environmental treatments for mental health and including the brain-gut-microbiome axis.
dc.fuente.origenWOS
dc.identifier.doi10.1002/bies.202100249
dc.identifier.eissn1521-1878
dc.identifier.issn0265-9247
dc.identifier.urihttps://doi.org/10.1002/bies.202100249
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93580
dc.identifier.wosidWOS:000773198500001
dc.issue.numero6
dc.language.isoen
dc.revistaBioessays
dc.rightsacceso restringido
dc.subject4E cognition
dc.subjectbuilt environment
dc.subjectgut-brain axis
dc.subjectmental health
dc.subjectmicrobiome
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe 4E approach to the human microbiome: Nested interactions between the gut-brain/body system within natural and built environments
dc.typeartículo
dc.volumen44
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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