Exploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy

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dc.contributor.authorMella, JG
dc.contributor.authorRoschmann, E
dc.contributor.authorGlasinovic, JC
dc.contributor.authorAlvarado, A
dc.contributor.authorScrivanti, M
dc.contributor.authorVolk, BA
dc.date.accessioned2025-01-21T01:34:08Z
dc.date.available2025-01-21T01:34:08Z
dc.date.issued1996
dc.description.abstractBackground/Aims: Intrahepatic cholestasis of pregnancy is a rare disease of unknown etiology, with a strikingly higher prevalence in Chile than in most other countries, Although several studies suggest that a genetic predisposition is involved in the pathogenesis, no genetic disease-marker has so far been identified, Using a recently developed HLA-genotyping technique, we performed an association study with a highly polymorphic HLA class II gene in patients with recurrent intrahepatic cholestasis of pregnancy and normal control patients.
dc.description.abstractMethods: Genomic DNA was extracted from 26 unrelated patients with recurrent ICP and 30 unrelated multiparous women without a personal or family history of this disease among a Chilean population, The polymorphic second exon of the HLA-DPB1 gene was amplified by the polymerase chain reaction and hybridized with 25 sequence-specific oligonucleotide probes to assign the HLA-DPB1 alleles on the basis of known sequence variations.
dc.description.abstractResults: Out of more than 50 HLA-DPB1 alleles presently known, 13 were represented in the analyzed groups. Patients with ICP had a higher frequency of the allele DPB1*0402 when compared to controls (69% vs 43%). This difference failed to reach statistical significance (chi(2)=2.81, corrected p>0.5). No significant differences were observed between the frequencies of other detected HLA-DPB1 alleles in the analyzed groups.
dc.description.abstractConclusion: In this study, we observed a high frequency of the allele HLA-DPB1*0402 among Chilean patients with recurrent ICP, but no association of the disease with HLA-DPB1 alleles, Therefore, HLA-DPB1 alleles do not play a major role in determining susceptibility or resistance to intrahepatic cholestasis of pregnancy.
dc.fuente.origenWOS
dc.identifier.eissn1600-0641
dc.identifier.issn0168-8278
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97520
dc.identifier.wosidWOS:A1996UD28700011
dc.issue.numero3
dc.language.isoen
dc.pagina.final323
dc.pagina.inicio320
dc.revistaJournal of hepatology
dc.rightsacceso restringido
dc.subjectgenetic susceptibility
dc.subjectHLA-DPB1
dc.subjectintrahepatic cholestasis of pregnancy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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