APOLIPOPROTEIN-E POLYMORPHISM IN PATIENTS WITH ACUTE-PANCREATITIS

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dc.contributor.authorROLLAN, A
dc.contributor.authorLOYOLA, G
dc.contributor.authorCOVARRUBIAS, C
dc.contributor.authorGIANCASPERO, R
dc.contributor.authorACEVEDO, K
dc.contributor.authorNERVI, F
dc.date.accessioned2024-01-10T13:11:10Z
dc.date.available2024-01-10T13:11:10Z
dc.date.issued1994
dc.description.abstractWe have shown that patients with previous acute pancreatitis (AP) may have an abnormal catabolism of chylomicron remnants (CMR). Because apoprotein E (Apo E) genetic polymorphism has an important influence on CMR clearance, we compared frequency distribution of Apo E phenotypes in 52 patients with AP, 109 patients with gallstones, and 110 control subjects. Apo E phenotypes were detected by isoelectric focusing and immunoblotting. After adjusting for differences in age and gender, fasting triglyceride level was comparable between the study groups. The frequency distribution of Apo E phenotypes was not different between the three study groups and it was in Hardy-Weinberg equilibrium. The gene frequency for Apo E2 was 0.212, 0.273, and 0.243 in AP, gallstone, and control group, respectively. For Apo E3 it was 0.701, 0.627, and 0.674, and for Apo E4 0.090, 0.100, and 0.083 in the same groups, respectively. Differences were not statistically significant (chi2). In conclusion, the abnormal catabolism of CMR in patients with AP is not attributable to Apo E polymorphism. An alternative explanation may be sought in the activity of the recently identified hepatocytic Apo E receptor [LDL-related receptor protein (LRP)].
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00006676-199405000-00011
dc.identifier.issn0885-3177
dc.identifier.pubmedidMEDLINE:7517545
dc.identifier.urihttps://doi.org/10.1097/00006676-199405000-00011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78008
dc.identifier.wosidWOS:A1994ND88400011
dc.information.autorucActividades Universitarias;Covarrubias C;S/I;98947
dc.information.autorucMedicina;Nervi F;S/I;99156
dc.information.autorucActividades Universitarias;Rollan A;S/I;100118
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final353
dc.pagina.inicio349
dc.publisherLIPPINCOTT-RAVEN PUBL
dc.revistaPANCREAS
dc.rightsacceso restringido
dc.subjectPANCREATITIS
dc.subjectAPO-E
dc.subjectGENETIC POLYMORPHISM
dc.subjectCHYLOMICRON
dc.subjectPROTEIN ALPHA-2-MACROGLOBULIN RECEPTOR
dc.subjectCHYLOMICRON REMNANT CLEARANCE
dc.subjectLIPOPROTEIN RECEPTOR
dc.subjectE ISOFORMS
dc.subjectSEQUENCE
dc.subjectPLASMA
dc.subjectHYPERLIPEMIA
dc.subjectCATABOLISM
dc.subjectPHENOTYPES
dc.subjectLOCUS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAPOLIPOPROTEIN-E POLYMORPHISM IN PATIENTS WITH ACUTE-PANCREATITIS
dc.typeartículo
dc.volumen9
sipa.codpersvinculados98947
sipa.codpersvinculados99156
sipa.codpersvinculados100118
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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