NEUROPEPTIDE Y (NPY) - A CORONARY VASOCONSTRICTOR AND POTENTIATOR OF CATECHOLAMINE-INDUCED CORONARY CONSTRICTION

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dc.contributor.authorMACHO, P
dc.contributor.authorPEREZ, R
dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorDOMENECH, RJ
dc.date.accessioned2025-01-23T19:23:45Z
dc.date.available2025-01-23T19:23:45Z
dc.date.issued1989
dc.description.abstractThe vasoactive effect of neuropeptide Y (NPY) a peptide commonly found in perivascular nerves, including those of the heart, was assessed in the coronary circulation of the isolated perfused dog heart and in superfused segments of isolated canine coronary arteries. The intracoronary administration of 0.7-23.5 nmol NPY to hearts during beta adrenergic blockade produced a dose-dependent increase in coronary vascular resistance ranging from 0.10 to 0.49 mmHg.cntdot.min-1.cntdot.ml-1.cntdot.100 g-1 without changes in myocardial oxygen consumption. The potency of NPY as a coronary vasoconstrictor was about 250 times that of noradrenaline. Pretreating the coronary system of these hearts with NPY caused a marked potentiation of the vasocontractile effect of noradrenaline, displacing its dose-response curve to the left in a non-parallel fashion. The addition of 0.2-3.7 nmol NPY did not induce contraction in superfused helical segments of large coronary arteries but it potentiated the tension developed in response to 0.18 .mu.M adrenaline in a concentration-dependent manner. Pretreatment of these arteries with 3.7 nmol NPY caused a significant leftward displacement of the adrenaline contractile effect. These results show that NPY is a potent coronary vasoconstrictor and a potentiator of the contractile effect of catecholamines and support the hypothesis that NPY may participate in the regulation of coronary vascular resistance.
dc.fuente.origenWOS
dc.identifier.eissn1879-0712
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99260
dc.identifier.wosidWOS:A1989AM16300008
dc.issue.numero1
dc.language.isoen
dc.pagina.final74
dc.pagina.inicio67
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleNEUROPEPTIDE Y (NPY) - A CORONARY VASOCONSTRICTOR AND POTENTIATOR OF CATECHOLAMINE-INDUCED CORONARY CONSTRICTION
dc.typeartículo
dc.volumen167
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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