Eosinophilic Cholecystitis and Eosinophils in Gallbladder Injuries: A Clinicopathological Analysis of 1050 Cholecystectomies

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dc.contributor.authorMemis, Bahar
dc.contributor.authorSaka, Burcu
dc.contributor.authorRoa, Juan Carlos
dc.contributor.authorBandyopadhyay, Sudeshna
dc.contributor.authorReid, Michelle
dc.contributor.authorBagci, Pelin
dc.contributor.authorAktas, Berk Kaan
dc.contributor.authorArmutlu, Ayse
dc.contributor.authorBasturk, Olca
dc.contributor.authorAdsay, N. Volkan
dc.date.accessioned2025-01-20T20:07:49Z
dc.date.available2025-01-20T20:07:49Z
dc.date.issued2023
dc.description.abstract"Eosinophilic cholecystitis" has been an elusive concept. Around 1050 consecutive cholecystectomies with chronic (CC, n = 895), subacute (SAC, n = 100), and acute cholecystitis (AC, n = 55) were reviewed for eosinophilic infiltration. Eosinophilic hot spots (>40 eosinophils/HPF) were seen in 63% of SAC and 35% of AC (vs. 6% of CC, p < 0.001). Eosinophils were mostly encountered in areas of wall thickening, revealing edema with early collagenization and young tissue-culture-type fibroblasts. However, in ten chronic cholecystitis patients (<1%), prominent eosinophilia with eosinophil-rich foci (>100 eosinophils/HPF) was noted. These ten cases, classified as "eosinophilic cholecystitis", were analyzed further: The patients were relatively young (mean age = 43 years), with a 9:1 female:male ratio. None had blood eosinophilia/eosinophilia syndromes. Although one had ulcerative colitis, others did not have any autoimmune diseases. The mean gallbladder wall thickness was 3.5 mm (vs. 4.2 mm in ordinary CC). In conclusion, eosinophils are a part of especially subacute injuries in the gallbladder. They are typically condensed in the areas of healing and appear to signify a distinctive state of injury in which there are erosions leading to slow/sustained exposure of the mural tissues to the bile contents that induce chemical injury/recruit eosinophils. Eosinophilic cholecystitis is a very uncommon occurrence and appears to be an exaggerated response in allergic patients who are prone to recruit eosinophils in reaction to injury.
dc.fuente.origenWOS
dc.identifier.doi10.3390/diagnostics13152559
dc.identifier.eissn2075-4418
dc.identifier.urihttps://doi.org/10.3390/diagnostics13152559
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91849
dc.identifier.wosidWOS:001046212300001
dc.issue.numero15
dc.language.isoen
dc.revistaDiagnostics
dc.rightsacceso restringido
dc.subjectcholecystectomy
dc.subjectcholecystitis
dc.subjectacute
dc.subjectsubacute
dc.subjectchronic
dc.subjecteosinophilic
dc.subjecteosinophils
dc.subjecthistopathology
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEosinophilic Cholecystitis and Eosinophils in Gallbladder Injuries: A Clinicopathological Analysis of 1050 Cholecystectomies
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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