Isolated axone of Wld<SUP>s</SUP> mice regrow centralward

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dc.contributor.authorIñiguez, A
dc.contributor.authorAlvarez, J
dc.date.accessioned2025-01-21T01:32:01Z
dc.date.available2025-01-21T01:32:01Z
dc.date.issued1999
dc.description.abstractWe have conjectured that axons embody a post transcriptional sprouting programme repressed by mature Schwann cells. Injured nerves of Wld(s) mice neither degenerate nor regenerate for several weeks but axone do regrow if the resident cells of the distal stump are destroyed. To test our hypothesis we made an extended crush in Wld(s) nerves to destroy resident cells, transected the nerve at the proximal end of the lesion, and searched for sprouts in the injured domain. These isolated axons regrew centralward as supported by ultrastructure, labelling with horseradish peroxidase, and staining with Dil. This result indicates that: (i) axons embody a post transcriptional sprouting programme; (ii) resident cells of the nerve, probably Schwann cells, repress this programme, and (III) navigation of regrowing axons is determined by the environment. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97187
dc.identifier.wosidWOS:000081021000014
dc.issue.numero2
dc.language.isoen
dc.pagina.final110
dc.pagina.inicio108
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectperipheral nerve
dc.subjectregeneration
dc.subjectSchwann cell
dc.subjectsprouting
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIsolated axone of Wld<SUP>s</SUP> mice regrow centralward
dc.typeartículo
dc.volumen268
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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