Laminin inhibits amyloid-beta-peptide fibrillation

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dc.contributor.authorBronfman, FC
dc.contributor.authorGarrido, J
dc.contributor.authorAlvarez, A
dc.contributor.authorMorgan, C
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:33:43Z
dc.date.available2025-01-21T01:33:43Z
dc.date.issued1996
dc.description.abstractLaminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (A beta) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/A beta protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit AP fibrillogenesis in vivo, specifically at the level of cerebral blood vessels.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97461
dc.identifier.wosidWOS:A1996VU69600015
dc.issue.numero3
dc.language.isoen
dc.pagina.final203
dc.pagina.inicio201
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectlaminin
dc.subjectamyloid-beta-peptide
dc.subjectAlzheimer's disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLaminin inhibits amyloid-beta-peptide fibrillation
dc.typeartículo
dc.volumen218
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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