Laminin inhibits amyloid-beta-peptide fibrillation
dc.contributor.author | Bronfman, FC | |
dc.contributor.author | Garrido, J | |
dc.contributor.author | Alvarez, A | |
dc.contributor.author | Morgan, C | |
dc.contributor.author | Inestrosa, NC | |
dc.date.accessioned | 2025-01-21T01:33:43Z | |
dc.date.available | 2025-01-21T01:33:43Z | |
dc.date.issued | 1996 | |
dc.description.abstract | Laminin, an important extracellular matrix component is induced by brain injury and colocalizes with amyloid-beta-peptide (A beta) deposits in Alzheimer brains. We report here that laminin inhibits amyloid fibril formation as determined by thioflavin T fluorescence spectroscopy and electron microscopic examination. The inhibition of amyloid formation by laminin was concentration dependent and was observed at a laminin concentration of 300 nM, corresponding to a laminin/A beta protein molar ratio of 1:800. The potential effect of laminin, may prove important to inhibit AP fibrillogenesis in vivo, specifically at the level of cerebral blood vessels. | |
dc.fuente.origen | WOS | |
dc.identifier.issn | 0304-3940 | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/97461 | |
dc.identifier.wosid | WOS:A1996VU69600015 | |
dc.issue.numero | 3 | |
dc.language.iso | en | |
dc.pagina.final | 203 | |
dc.pagina.inicio | 201 | |
dc.revista | Neuroscience letters | |
dc.rights | acceso restringido | |
dc.subject | laminin | |
dc.subject | amyloid-beta-peptide | |
dc.subject | Alzheimer's disease | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Laminin inhibits amyloid-beta-peptide fibrillation | |
dc.type | artículo | |
dc.volumen | 218 | |
sipa.index | WOS | |
sipa.trazabilidad | WOS;2025-01-12 |