Theta modulation of hippocampal activity during distinct brain states

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dc.catalogadorpva
dc.contributor.advisorFuentealba, Pablo
dc.contributor.authorCaneo Contreras, Mauricio Andrés
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Ciencias Biológicas
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Ciencias Sociales
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Química y Farmacia
dc.contributor.otherPontificia Universidad Católica de Chile. Facultad de Medicina
dc.date2025-05-21
dc.date.accessioned2025-05-06T19:30:52Z
dc.date.issued2025
dc.date.updated2025-04-21T18:49:02Z
dc.descriptionTesis (Doctor en Neurociencias)--Pontificia Universidad Católica de Chile, 2025
dc.description.abstractTheta oscillations in the brain play a pivotal role in coordinating behavior across different states. We characterized how distinct brain states (wakefulness and sleep) modulate theta oscillations and associated neural activity in the hippocampus (CA1d and DG) and subcortical regions (SuM, LS, and HyP). Using electrophysiological recordings, we found that theta power and frequency in CA1d and SuM are significantly higher during active exploration (AE) compared to REM sleep. Functional connectivity, evaluated through phase coherence, revealed increased synchrony between CA1d-SuM and SuM-DG pairs during AE. Spike activity exhibited higher firing rates during AE and quiet wakefulness (QW) compared to REM sleep, with stronger spike-theta coupling observed in REM sleep. Additionally, changes in theta power in CA1d, DG, LS, and HyP correlated with speed and acceleration during AE, indicating that these oscillations dynamically reflect locomotor parameters. Our findings underscore how theta oscillations and neural activity adapt to different brain states to support sensorimotor integration and cognitive functions. 
dc.description.funderFONDECYT
dc.description.funderProject Anillo
dc.description.funderANID
dc.description.version2025-05-21
dc.fechaingreso.objetodigital2025-04-21
dc.format.extent108 páginas
dc.fuente.origenAutoarchivo
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104033
dc.information.autorucFacultad de Ciencias Biológicas; Fuentealba, Pablo; 0000-0002-9679-4612; 19184
dc.information.autorucEscuela de Medicina; Caneo Contreras, Mauricio Andrés; S/I; 1092187
dc.language.isoen
dc.nota.accesocontenido completo
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTheta modulation of hippocampal activity during distinct brain states
dc.typetesis doctoral
sipa.codpersvinculados19184
sipa.codpersvinculados1092187
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