Characterization of Oral Health Status in Chilean Patients with X-Linked Hypophosphatemia

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dc.contributor.authorMarin, Alejandro
dc.contributor.authorMorales, Pilar
dc.contributor.authorJimenez, Macarena
dc.contributor.authorBorja, Eugenia
dc.contributor.authorIvanovic-Zuvic, Danisa
dc.contributor.authorCollins, Michael T.
dc.contributor.authorFlorenzano, Pablo
dc.date.accessioned2025-01-20T23:51:48Z
dc.date.available2025-01-20T23:51:48Z
dc.date.issued2021
dc.description.abstractX-Linked Hypophosphatemia (XLH) is the most common cause of inherited hypophosphatemic rickets. Dental involvement, including spontaneous abscesses and/or fistulae, is an important part of the disease and has not been completely defined, especially in cohorts from developing countries. To describe oral health status in a cohort of Chilean patients with XLH and explore its correlation with biochemical presentation and treatment, we conducted a cross-sectional observational study of patients with PHEX mutation-confirmed XLH. All patients had an oral clinical exam, radiographic evaluation; clinical and biochemical data were obtained to determine their association with oral features. Twenty-six patients were included, 77% adults and 23% children. Most adults (89%) had past or current dental pulp pathology (abscesses and/or fistulae). Pulpal chamber enlargement and radiolucent apical lesions were common radiological features (94 and 74%, respectively). In children, abscess and/or fistulae were also common (33%). Caries index, which was determined by dmft/DMFT, was higher than the Chilean national average. Early and long-term therapy with phosphate and activated vitamin D was associated with lower carious index and attachment loss. XLH patients frequently present with high pulpal involvement and carious index. Conventional therapy was associated with lower carious index and attachment loss. These data highlight the importance of early and periodical dental care in order to prevent dental damage and assure a good quality of oral health for XLH patients.
dc.description.funderUltragenyx
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00223-021-00841-4
dc.identifier.eissn1432-0827
dc.identifier.issn0171-967X
dc.identifier.urihttps://doi.org/10.1007/s00223-021-00841-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94858
dc.identifier.wosidWOS:000638814700002
dc.issue.numero2
dc.language.isoen
dc.pagina.final138
dc.pagina.inicio132
dc.revistaCalcified tissue international
dc.rightsacceso restringido
dc.subjectHypophosphatemic rickets
dc.subjectX-linked hypophosphatemia
dc.subjectFGF23
dc.subjectSpontaneous abscess
dc.subjectSpontaneous fistulae
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCharacterization of Oral Health Status in Chilean Patients with X-Linked Hypophosphatemia
dc.typeartículo
dc.volumen109
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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