Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes

Simple item page
dc.contributor.authorOrellana, J. A.
dc.contributor.authorVelasquez, S.
dc.contributor.authorWilliams, D. W.
dc.contributor.authorSaez, J. C.
dc.contributor.authorBerman, J. W.
dc.contributor.authorEugenin, E. A.
dc.date.accessioned2025-01-24T00:08:56Z
dc.date.available2025-01-24T00:08:56Z
dc.date.issued2013
dc.description.abstractPannexin-1 hemichannels as key regulators of HIV infection and replication in human T lymphocytes. HIV is a major public health issue, and infection of CD4(+) T lymphocytes is one of its key features. Whereas several cellular proteins have been identified that facilitate viral infection and replication, the role of hemichannels in these processes has not been fully characterized. We now show that the HIV isolates, R5 and X4, induced a transient-early (5-30 min) and a later, persistent (48-120 h) opening of Panx1 hemichannels, which was dependent on the binding of HIV to CD4 and CCR5/CXCR4 receptors. Blocking Panx1 hemichannels by reducing their opening or protein expression inhibited HIV replication in CD4(+) T lymphocytes. Thus, our findings demonstrate that Panx1 hemichannels play an essential role in HIV infection.
dc.fechaingreso.objetodigital2025-06-02
dc.fuente.origenWOS
dc.identifier.doi10.1189/jlb.0512249
dc.identifier.eissn1938-3673
dc.identifier.issn0741-5400
dc.identifier.urihttps://doi.org/10.1189/jlb.0512249
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101974
dc.identifier.wosidWOS:000328839400004
dc.issue.numeroNo. 3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final407
dc.pagina.inicio399
dc.revistaJournal of leukocyte biology
dc.rightsacceso restringido
dc.subjectAIDS
dc.subjectchannels
dc.subjectdisease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
dc.typeartículo
dc.volumenVol. 94
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes.pdf
Size:
24.17 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas