Genomic structure of yellow lupin (Lupinus luteus): genome organization, evolution, gene family expansion, metabolites and protein synthesis

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dc.article.number477
dc.catalogadorpva
dc.contributor.authorMartinez-Hernandez, J. E.
dc.contributor.authorSalvo-Garrido, Haroldo
dc.contributor.authorLevicoy, Daniela
dc.contributor.authorCaligari, Peter D. S.
dc.contributor.authorRupayán, Annally
dc.contributor.authorMoyano Yugovic, Tomás Custodio
dc.contributor.authorCarrasco, Makarena
dc.contributor.authorHernandez, Sebastián
dc.contributor.authorArmijo-Godoy, Grace
dc.contributor.authorWestermeyer, Fernando
dc.contributor.authorLarama, Giovanni
dc.date.accessioned2025-05-28T16:18:06Z
dc.date.available2025-05-28T16:18:06Z
dc.date.issued2025
dc.date.updated2025-05-18T00:03:00Z
dc.description.abstractYellow lupin (Lupinus luteus) gives valuable high-quality protein and has good sustainability due to its ability in nitrogen fixation and exudation of organic acids, which reduces the need for chemical-based phosphate fertilization in acid soils. However, the crop needs further improvements to contribute in a major way to sustainable agriculture and food security. In this study, we present the first chromosome-level genome assembly of L. luteus. The results provide insights into its genomic organization, evolution, and functional attributes. Using integrated genomic approaches, we unveil the genetic bases governing its adaptive responses to environmental stress, delineating the intricate interplay among alkaloid biosynthesis, mechanisms of pathogen resistance, and secondary metabolite transporters. Our comparative genomic analysis of closely related species highlights recent speciation events within the Lupinus genus, exposing extensive synteny preservation alongside notable structural alterations, particularly chromosome translocations. Remarkable expansions of gene families implicated in terpene metabolism, stress responses, and conglutin proteins were identified, elucidating the genetic basis of L. luteus’ superior nutritional profile and defensive capabilities. Additionally, a diverse array of disease resistance-related (R) genes was uncovered, alongside the characterization of pivotal enzymes governing quinolizidine alkaloid biosynthesis, thus shedding light on the molecular mechanisms underlying “bitterness” in lupin seeds. This comprehensive genomic analysis serves as a valuable resource to improve this species in terms of resilience, yield, and seed protein levels to contribute to food and feed to face the worldwide challenge of sustainable agriculture and food security.
dc.fechaingreso.objetodigital2025-05-18
dc.format.extent20 páginas
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Genomics. 2025 May 14;26(1):477
dc.identifier.doi10.1186/s12864-025-11678-8
dc.identifier.urihttps://doi.org/10.1186/s12864-025-11678-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104504
dc.information.autorucFacultad de Ciencias Biológicas; Moyano Yugovic, Tomás Custodio; S/I; 149778
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaBMC Genomics
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectLupinus luteus
dc.subjectGenome assembly
dc.subjectChromosomal rearrangements
dc.subjectProtein and metabolites biosynthesis
dc.subject02 Hambre cero
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.subject.ods02 Zero hunger
dc.titleGenomic structure of yellow lupin (Lupinus luteus): genome organization, evolution, gene family expansion, metabolites and protein synthesis
dc.typeartículo
dc.volumen26
sipa.codpersvinculados149778
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