The Gut-Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction

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dc.catalogadorgjm
dc.contributor.authorRivera Vega, Katherine Solange
dc.contributor.authorGonzalez, Leticia
dc.contributor.authorBravo Urquiza, Liena Martina
dc.contributor.authorManjarrés Madrid, Laura
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.date.accessioned2025-03-06T18:56:37Z
dc.date.available2025-03-06T18:56:37Z
dc.date.issued2024
dc.description.abstractMyocardial infarction (MI) remains the leading cause of death globally, imposing a significant burden on healthcare systems and patients. The gut-heart axis, a bidirectional network connecting gut health to cardiovascular outcomes, has recently emerged as a critical factor in MI pathophysiology. Disruptions in this axis, including gut dysbiosis and compromised intestinal barrier integrity, lead to systemic inflammation driven by gut-derived metabolites like lipopolysaccharides (LPSs) and trimethylamine N-oxide (TMAO), both of which exacerbate MI progression. In contrast, metabolites such as short-chain fatty acids (SCFAs) from a balanced microbiota exhibit protective effects against cardiac damage. This review examines the molecular mediators of the gut-heart axis, considering the role of factors like sex-specific hormones, aging, diet, physical activity, and alcohol consumption on gut health and MI outcomes. Additionally, we highlight therapeutic approaches, including dietary interventions, personalized probiotics, and exercise regimens. Addressing the gut-heart axis holds promise for reducing MI risk and improving recovery, positioning it as a novel target in cardiovascular therapy.
dc.fechaingreso.objetodigital2025-03-06
dc.format.extent25 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms252212465
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms252212465
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102410
dc.identifier.wosidWOS:001365471100001
dc.information.autorucEscuela de Medicina; Rivera Vega, Katherine Solange; S/I; 1063705
dc.information.autorucEscuela de Medicina; Gonzalez, Leticia; S/I; 1061572
dc.information.autorucFacultad de Ciencias Biológicas; Bravo Urquiza, Liena Martina; S/I; 1067812
dc.information.autorucEscuela de Medicina; Manjarrés Madrid, Laura; S/I; 1183087
dc.information.autorucEscuela de Medicina; Andía Kohnenkampf, Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.issue.numero22
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMyocardial infarction
dc.subjectGut-heart axis
dc.subjectGut microbiota
dc.subjectIntestinal barrier
dc.subjectGut metabolites
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Gut-Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction
dc.typeartículo de revisión
dc.volumen25
sipa.codpersvinculados1063705
sipa.codpersvinculados1061572
sipa.codpersvinculados1067812
sipa.codpersvinculados1183087
sipa.codpersvinculados90691
sipa.trazabilidadWOS;2024-12-14
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