Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation

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dc.catalogadorvzp
dc.contributor.authorOcaranza Jeraldino, Maria Paz
dc.contributor.authorJalil Milad, Jorge Emilio
dc.contributor.authorAltamirano Assad, Rodrigo Patricio
dc.contributor.authorDe León Soto, Ana María
dc.contributor.authorMoya López, Jackeline Trinidad
dc.contributor.authorLonis Álvarez, María Alejandra
dc.contributor.authorGabrielli Nervi, Luigi Arnaldo
dc.contributor.authorMac Nab, Paul
dc.contributor.authorCordova Alvestegui, Samuel Edmundo
dc.contributor.authorParedes, Alejandro
dc.contributor.authorVergara Saavedra, Ismael Antonio
dc.contributor.authorBittner Braemer, Alex Gerhard
dc.contributor.authorSabat Sarras, Karime Alejandra
dc.contributor.authorPastorini, Karla
dc.date.accessioned2024-06-05T16:37:27Z
dc.date.available2024-06-05T16:37:27Z
dc.date.issued2021
dc.description.abstract["Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction in HFrEF patients. Cardiac resynchronization therapy (CRT) is effective in HFrEF, especially when there is a left bundle block, as this treatment may stimulate reverse remodeling, thereby improving quality of life and prolonging survival for patients with this severe condition. Here, we evaluate the hypothesis that ROCK activation is reduced after effective CRT in HFrEF.", "Methods: ROCK activation in circulating leukocytes was evaluated in 28 HFrHF patients, using Western blot (myosin light chain phosphatase subunit 1 phosphorylation, MYPT1p/t), before and three months after initiation of CRT. LV systolic function and remodeling were assessed by echocardiography.", "Results: Three months after CRT, LV ejection fraction increased an average of 14.5% (p < 0.001) in 13 patients (responders), while no change was observed in 15 patients (non-responders). End-systolic diameter decreased 16% (p < 0.001) in responders, with no change in non-responders. ROCK activation in PBMCs decreased 66% in responders (p < 0.05) but increased 10% in non-responders (NS). LV end-diastolic diameter was also 5.2 mm larger in non-responders vs. responders (p = 0.058). LV ejection fraction, systolic diameter, and ROCK activation levels were similar in both groups at baseline.", "Conclusion: In HFrEF patients, 3 months of effective CRT induced reverse myocardial remodeling, and ROCK activation was significantly decreased in circulating leukocytes. Thus, decreased ROCK activation in circulating leukocytes may reflect reverse cardiac remodeling in patients with heart failure."]
dc.fechaingreso.objetodigital2024-06-05
dc.format.extent10 páginas
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.3389/fphar.2021.565724
dc.identifier.issn1663-9812
dc.identifier.pubmedidMEDLINE:33967744
dc.identifier.scopusid000648038100001
dc.identifier.urihttp://dx.doi.org/10.3389/fphar.2021.565724
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86463
dc.identifier.wosidWOS:000648038100001
dc.information.autorucEscuela de Medicina; Ocaranza Jeraldino, María Paz; 0000-0002-4915-6378; 1001254
dc.information.autorucEscuela de Medicina; Jalil Milad, Jorge Emilio; 0000-0001-6877-2072; 99946
dc.information.autorucEscuela de Medicina; Altamirano Assad, Rodrigo Patricio; S/I; 175081
dc.information.autorucEscuela de Medicina; De León Soto, Ana María; S/I; 209504
dc.information.autorucEscuela de Medicina; Moya López, Jackeline Trinidad; S/I; 1011146
dc.information.autorucEscuela de Medicina; Lonis Alvarez, Maria Alejandra; S/I; 1083914
dc.information.autorucEscuela de Medicina; Gabrielli Nervi, Luigi Arnaldo; 0000-0002-1551-7147; 11086
dc.information.autorucEscuela de Medicina; Cordova Alvestegui, Samuel Edmundo; S/I; 96819
dc.information.autorucEscuela de Medicina; Vergara Saavedra, Ismael Antonio; S/I; 73862
dc.information.autorucEscuela de Medicina; Bittner Braemer, Alex Gerhard; S/I; 1000416
dc.information.autorucEscuela de Medicina; Sabat Sarras, Karime Alejandra; S/I; 247630
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final10
dc.pagina.inicio1
dc.revistaFRONTIERS IN PHARMACOLOGY
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1001254
sipa.codpersvinculados99946
sipa.codpersvinculados175081
sipa.codpersvinculados209504
sipa.codpersvinculados1011146
sipa.codpersvinculados1083914
sipa.codpersvinculados11086
sipa.codpersvinculados96819
sipa.codpersvinculados73862
sipa.codpersvinculados1000416
sipa.codpersvinculados247630
sipa.trazabilidadConveris;20-07-2021
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