Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits

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dc.contributor.authorPetty, Lauren E.
dc.contributor.authorChen, Hung-Hsin
dc.contributor.authorFrankel, Elizabeth G.
dc.contributor.authorZhu, Wanying
dc.contributor.authorDownie, Carolina G.
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorLin, Phillip
dc.contributor.authorSharma, Priya
dc.contributor.authorZhang, Xinruo
dc.contributor.authorScartozzi, Alyssa C.
dc.contributor.authorRoshani, Rashedeh
dc.contributor.authorLandman, Joshua M.
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBowden, Donald W.
dc.contributor.authorChambers, John C.
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMcCarthy, Mark I.
dc.contributor.authorNg, Maggie C. Y.
dc.contributor.authorSim, Xueling
dc.contributor.authorSpracklen, Cassandra N.
dc.contributor.authorZhang, Weihua
dc.contributor.authorPreuss, Michael
dc.contributor.authorBottinger, Erwin P.
dc.contributor.authorNadkarni, Girish N.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorTan, Jingyi
dc.contributor.authorIpp, Eli
dc.contributor.authorGenter, Pauline
dc.contributor.authorEmery, Leslie S.
dc.contributor.authorLouie, Tin
dc.contributor.authorSofer, Tamar
dc.contributor.authorStilp, Adrienne M.
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorXiang, Anny H.
dc.contributor.authorBuchanan, Thomas A.
dc.contributor.authorRoll, Kathryn
dc.contributor.authorGao, Chuan
dc.contributor.authorPalmer, Nicholette D.
dc.contributor.authorNorris, Jill M.
dc.contributor.authorWagenknecht, Lynne E.
dc.contributor.authorNousome, Darryl
dc.contributor.authorVarma, Rohit
dc.contributor.authorMcKean-Cowdin, Roberta
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorHai, Yang
dc.contributor.authorHsueh, Willa
dc.contributor.authorSandow, Kevin
dc.contributor.authorParra, Esteban J.
dc.contributor.authorCruz, Miguel
dc.contributor.authorValladares-Salgado, Adan
dc.contributor.authorWacher-Rodarte, Niels
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorGoodarzi, Mark O.
dc.contributor.authorRich, Stephen S.
dc.contributor.authorBertoni, Alain
dc.contributor.authorRaffel, Leslie J.
dc.contributor.authorNadler, Jerry L.
dc.contributor.authorKandeel, Fouad R.
dc.contributor.authorDuggirala, Ravindranath
dc.contributor.authorBlangero, John
dc.contributor.authorLehman, Donna M.
dc.contributor.authorDeFronzo, Ralph A.
dc.contributor.authorThameem, Farook
dc.contributor.authorWang, Yujie
dc.contributor.authorGahagan, Sheila
dc.contributor.authorBlanco, Estela
dc.contributor.authorBurrows, Raquel
dc.contributor.authorHuerta-Chagoya, Alicia
dc.contributor.authorFlorez, Jose C.
dc.contributor.authorTusie-Luna, Teresa
dc.contributor.authorGonzalez-Villalpando, Clicerio
dc.contributor.authorOrozco, Lorena
dc.contributor.authorHaiman, Christopher A.
dc.contributor.authorHanis, Craig L.
dc.contributor.authorRohde, Rebecca
dc.contributor.authorWhitsel, Eric A.
dc.contributor.authorReiner, Alexander P.
dc.contributor.authorKooperberg, Charles
dc.contributor.authorLi, Yun
dc.contributor.authorDuan, Qing
dc.contributor.authorLee, Miryoung
dc.contributor.authorCorrea-Burrows, Paulina
dc.contributor.authorFried, Susan K.
dc.contributor.authorNorth, Kari E.
dc.contributor.authorMcCormick, Joseph B.
dc.contributor.authorFisher-Hoch, Susan P.
dc.contributor.authorGamazon, Eric R.
dc.contributor.authorMorris, Andrew P.
dc.contributor.authorMercader, Josep M.
dc.contributor.authorHighland, Heather M.
dc.contributor.authorBelow, Jennifer E.
dc.date.accessioned2025-12-15T10:30:20Z
dc.date.available2025-12-15T10:30:20Z
dc.date.issued2025
dc.description.abstractHere, we present a multi-omics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits conducted to date in Hispanic/Latino populations (nmax = 63,184). We conduct a meta-analysis of 16 type 2 diabetes and 19 lipid trait GWAS, identifying 20 genome-wide significant loci for type 2 diabetes, including one novel locus and novel signals at two known loci, based on fine-mapping. We also identify sixty-one genome-wide significant loci across the lipid/lipoprotein traits, including nine novel loci, and novel signals at 19 known loci through fine-mapping. Next, we analyze genetically regulated expression, perform Mendelian randomization, and analyze association with transcriptomic and proteomic measure using multi-omics data from a Hispanic/Latino population. Using this approach, we identify genes linked to type 2 diabetes and lipid/lipoprotein traits, including TMEM205 and NEDD9 for HDL cholesterol, TREH for triglycerides, and ANXA4 for type 2 diabetes.
dc.description.funderChilean Agencia Nacional de Investigacion y Desarrollo (ANID) under FONDECYT
dc.format.extent28 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41467-025-58574-z
dc.identifier.eissn2041-1723
dc.identifier.issn0328-1396
dc.identifier.scopusidSCOPUS_ID:105003323438
dc.identifier.urihttps://doi.org/10.1038/s41467-025-58574-z
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107398
dc.identifier.wosidWOS:001465426800011
dc.information.autorucEscuela de Medicina; Blanco, Estela; S/I; 1232774
dc.information.autorucNo Informado
dc.information.autorucNo Informado; Blanco No Informado, Estela; S/I; 1232774
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final140
dc.pagina.inicio113
dc.publisherSpringer Science and Business Media B.V.
dc.relation.ispartofA Sociopolitical Turn in Science Education: Towards Post-pandemic Worlds
dc.revistaNATURE COMMUNICATIONS
dc.rightsregistro bibliográfico
dc.subject"Vota" of the Bishops about Religious Life
dc.subjectSecond Vatican Council
dc.subjectReligious Life
dc.subjectPreconciliar Ecclesiology
dc.subjectAntepreparatory Period
dc.subjectChurch in Latin America and the Caribbean
dc.subject.ddc370
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLarge-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
dc.typeartículo
dc.volumen16
sipa.codpersvinculados1232774
sipa.codpersvinculados1232774
sipa.indexScopus
sipa.indexWOS
sipa.trazabilidadWOS-SCOPUS;2025-12-15
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