KAPPA-OPIATE-INDUCED DIURESIS AND CHANGES IN BLOOD-PRESSURE - DEMONSTRATION OF RECEPTOR STEREOSELECTIVITY USING (+)-TIFLUADOM AND (-)-TIFLUADOM

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dc.contributor.authorURETA, H
dc.contributor.authorLOPEZ, LF
dc.contributor.authorPEREZ, A
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:25:52Z
dc.date.available2025-01-23T19:25:52Z
dc.date.issued1987
dc.description.abstract(+)-Tifluadom injected i.p. produced a biphasic response of urine output: within the first hour of its administration the drug produced antidiuresis followed by a diuretic phase. In contrast, the (-) isomer produced a modest reduction in urine output as compared to the output of the saline-treated rats. In addition, (+)-tifluadom markedly reduced the output of urinary Na+ and K+. The effects of (+)-tifluadom were blocked by 7.5 mg/kg naloxone but not by 10 mg/kg of the benzodiazepine antagonist Ro 15-1788. Parallel experiments demonstrated that the i.v. administration of (+)-tifluadom to non-anesthetized rats caused a dose-related pressor response that lasted for at least 15 min. This effect of (+)-tifluadom wa blocked and antagonized by naloxone. In contrast, (-)-tifluadom was either inactive on the cardiovascular system or produced short-lasting hypotension. In pentobarbital-anesthetized rats, 100 .mu.g/kg (+)-tifluadom caused a precipitous hypotension that was reversed by naloxone but not by Ro 15-1788.
dc.fuente.origenWOS
dc.identifier.eissn1879-0712
dc.identifier.issn0014-2999
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99535
dc.identifier.wosidWOS:A1987G920400002
dc.issue.numero3
dc.language.isoen
dc.pagina.final295
dc.pagina.inicio289
dc.revistaEuropean journal of pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleKAPPA-OPIATE-INDUCED DIURESIS AND CHANGES IN BLOOD-PRESSURE - DEMONSTRATION OF RECEPTOR STEREOSELECTIVITY USING (+)-TIFLUADOM AND (-)-TIFLUADOM
dc.typeartículo
dc.volumen135
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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