INHIBITION OF STRESS-INDUCED HYPERGLYCEMIA BY TAIL PINCHING OR INTRAVENTRICULAR ENKEPHALIN ADMINISTRATION IN THE RAT

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dc.contributor.authorSANCHEZ, R
dc.contributor.authorVARGAS, L
dc.date.accessioned2025-01-23T19:24:44Z
dc.date.available2025-01-23T19:24:44Z
dc.date.issued1988
dc.description.abstractThe tail pinch (t-p) method added to a basal restraint stress produced inhibition of the stress-induced hyperglycemia, an effect that was neutralized with intrathecal anesthesia but not with intracerebroventricular (i.c.v.) naloxone (50, 100, 1000 ng/100 g) or with intraperitoneal naloxone injections (0.1-0.3 mg/100 g). A similar negative result was obtained with i.c.v. administration of 500 and 1000 ng/100 g of .beta.-endorphin. In contrast, a single i.c.v. injection of 1000 ng/100 g of Met-enkephalin reproduced the t-p inhibitory effect. The latter was not elicited by i.c.v. FK 33824, an enkephalin analogue, a result that supports the specific participation of the .delta.-opioid receptors. The results obtained with central .alpha.-adrenoceptor antagonists and central noradrenergic chemical destruction, or central .alpha.-adrenoceptor agonists, support the production of a reinforcement of the .alpha.-adrenoceptor stress stimulation by the t-p procedure, probably through noradrenaline and enkephalin mediation.
dc.fuente.origenWOS
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99394
dc.identifier.wosidWOS:A1988N856900018
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final155
dc.pagina.inicio149
dc.revistaBrain research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleINHIBITION OF STRESS-INDUCED HYPERGLYCEMIA BY TAIL PINCHING OR INTRAVENTRICULAR ENKEPHALIN ADMINISTRATION IN THE RAT
dc.typeartículo
dc.volumen452
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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