ADRENAL AND LIVER PARTICIPATION IN RATS POST-STRESS DIABETIC RESPONSE

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dc.contributor.authorVARGAS, I
dc.contributor.authorKAWADA, ME
dc.date.accessioned2025-01-23T19:45:03Z
dc.date.available2025-01-23T19:45:03Z
dc.date.issued1976
dc.description.abstractSixty minutes of restraint stress, preceded by chlorpromazine administration which stimulates somatotropic hormone secretion (STH), produced an acute post-stress diabetic response (PDR) in normal-intact rats and in adrenalectomized rats. This PDR lasted 3-4 h and was evaluated by glucemia and glucosuria determination and by the appearance of an insulin antagonist, .alpha.2-glycoprotein STH-dependent, called .alpha.2-inhibitor, which inhibits glucose uptake by isolated tissues. When tested in the suprahepatic blood of animals after stress it showed increased activity in normal and in adrenalectomized rats. .alpha.2-Inhibitor may be produced in the liver by the action of STH and without primary glucocorticoid participation. The post-stress hyperglucemic response of adrenalectomized rats had a similar tendency to that of the control, although with initial and final values of glucemia significantly below the control. This response supports the idea that postadrenalectomy gluconeogenesis was evoked during and after the systemic stress.
dc.fuente.origenWOS
dc.identifier.eissn1439-4286
dc.identifier.issn0018-5043
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100192
dc.identifier.wosidWOS:A1976CG21600014
dc.issue.numero5
dc.language.isoen
dc.pagina.final388
dc.pagina.inicio383
dc.revistaHormone and metabolic research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleADRENAL AND LIVER PARTICIPATION IN RATS POST-STRESS DIABETIC RESPONSE
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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