URINARY KALLIKREIN ACTIVITY DURING RAT PREGNANCY

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dc.contributor.authorSALAS, SP
dc.contributor.authorROBLERO, JS
dc.contributor.authorCROXATTO, HR
dc.contributor.authorVALDES, G
dc.date.accessioned2025-01-23T19:25:23Z
dc.date.available2025-01-23T19:25:23Z
dc.date.issued1987
dc.description.abstractChanges in urinary kallikrein activity and its possible correlation with changes in blood pressure and renal excretory function during pregnancy were studied in the rat. To establish a possible physiological role of kallikrein in this condition aprotinin, which inhibits kallikrein as well as other serine protease was administered to pregnant rats. Urinary kallikrein activity was markedly increased during pregnancy and correlated positively with urine volume and electrolytes excretion, but not with blood pressure. Aprotinin administration almost completely inhibited kallikrein activity, however, blood pressure levels, urine volume and electrolytes were not changed after one day of aprotinin treatment. In conclusion, although renal kallikrein is highly enhanced during pregnancy, its physiologic role in this condition remains elusive.
dc.fuente.origenWOS
dc.identifier.issn0004-0533
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99472
dc.identifier.wosidWOS:A1987N366200004
dc.issue.numero3-4
dc.language.isoen
dc.pagina.final309
dc.pagina.inicio305
dc.revistaArchivos de biologia y medicina experimentales
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleURINARY KALLIKREIN ACTIVITY DURING RAT PREGNANCY
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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