Pre-operative high-frequency ultrasound: a reliable management tool in auricular and nasal non-melanoma skin cancer

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dc.contributor.authorCrisan, Diana
dc.contributor.authorWortsman, Ximena
dc.contributor.authorCatalano, Orlando
dc.contributor.authorBadea, Radu
dc.contributor.authorKastler, Sabine
dc.contributor.authorBadea, Alexandru
dc.contributor.authorManea, Avram
dc.contributor.authorScharffetter-Kochanek, Karin
dc.contributor.authorStrilciuc, Stefan
dc.contributor.authorCrisan, Maria
dc.contributor.authorSchneider, Lars Alexander
dc.date.accessioned2025-01-20T17:10:14Z
dc.date.available2025-01-20T17:10:14Z
dc.date.issued2024
dc.description.abstractBackground and objectives: The knowledge of depth infiltration in non-melanoma skin cancer (NMSC) using pre-operative ultrasound could enable clinicians to choose the most adequate therapeutic approach, avoiding unnecessary surgeries and expensive imaging methods, delaying diagnosis and treatment. Our single-center retrospective study determined the usefulness of high-frequency ultrasound (HFUS) for depth infiltration assessment in auricular and nasal NMSC and assessed the subsequent change in therapeutic approach.Patients and Methods: In 60 NMSC cases, we assessed the accuracy of HFUS in cartilaginous/bone infiltration detection as well as the correlation of sonographic and histological parameters.Results: In 16.6% of cases, a deep cartilaginous/bone involvement or locoregional disease was identified pre-operatively, resulting in a changed therapeutical scheme of radio-immunological treatment rather than surgery. In two cases, pre-operative HFUS identified local cartilage infiltration, reducing the number of surgical procedures. Forty-eight remaining lesions with no depth infiltration were excised; a correlation of > 99% between the histologic and sonographic tumor depth (p<0.001) was found.Conclusions: Pre-surgical HFUS influences the therapeutic management in NMSC by detecting subclinical involvement of deeper structures, avoiding more extensive diagnostics, reducing costs, and improving healthcare quality. High-frequency ultrasound should be implemented in dermatosurgery before tumor excision for optimized therapy and improved patient counseling.
dc.description.funderProjekt DEAL
dc.fuente.origenWOS
dc.identifier.doi10.1111/ddg.15308
dc.identifier.eissn1610-0387
dc.identifier.issn1610-0379
dc.identifier.urihttps://doi.org/10.1111/ddg.15308
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91092
dc.identifier.wosidWOS:001146065300001
dc.language.isoen
dc.revistaJournal der deutschen dermatologischen gesellschaft
dc.rightsacceso restringido
dc.subjectskin cancer
dc.subjectultrasound
dc.subjectskin imaging
dc.subjectsurgery
dc.subjectsystemic therapy
dc.titlePre-operative high-frequency ultrasound: a reliable management tool in auricular and nasal non-melanoma skin cancer
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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