Classification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading

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dc.contributor.authorAravena, Carolina
dc.contributor.authorBozkurt, Kansu
dc.contributor.authorChuephanich, Pichaya
dc.contributor.authorSupiyaphun, Chantaka
dc.contributor.authorYu, Fei
dc.contributor.authorDeng, Sophie X.
dc.date.accessioned2024-01-10T13:11:46Z
dc.date.available2024-01-10T13:11:46Z
dc.date.issued2019
dc.description.abstractPurpose: To grade the severity of limbal stem cell deficiency (LSCD) based on the extent of clinical presentation and central corneal basal epithelial cell density (BCD).
dc.description.abstractMethods: This is a retrospective observational comparative study of 48 eyes of 35 patients with LSCD and 9 eyes of 7 normal subjects (controls). Confocal images of the central cornea were acquired. A clinical scoring system was created based on the extent of limbal and corneal surface involvement. LSCD was graded as mild, moderate, and severe stages based on the clinical scores. The degree of BCD reduction was given a score of 0 to 3.
dc.description.abstractResults: Compared with BCD in controls, BCD decreased by 23.0%, 40.4%, and 69.5% in the mild, moderate, and severe stages of LSCD classified by the clinical scoring system, respectively. The degree of BCD reduction was positively correlated with larger limbal and corneal surface involvement and when the central visual axis was affected (all P <= 0.0005). Mean corrected distance visual acuity logarithm of the minimum angle of resolution was 0.0 +/- 0.0 in control eyes, 0.2 +/- 0.5 in mild LSCD, 0.6 +/- 0.4 in moderate LSCD, and 1.6 +/- 1.1 in severe LSCD (P< 0.0001). There was a significant correlation between a higher clinical score and corrected distance visual acuity logarithm of the minimum angle of resolution (rho = 0.82; P< 0.0001) and a greater decrease in BCD (rho = 20.78; P< 0.0001).
dc.description.abstractConclusions: A clinical scoring system was developed to assess the extent of clinical presentation of LSCD. A classification system to grade the severity of LSCD can be established by combining the BCD score with the clinical score.
dc.description.funderCalifornia Institute for Regenerative Medicine
dc.description.funderResearch to Prevent Blindness
dc.description.funderNational Eye Institute
dc.description.funderNATIONAL EYE INSTITUTE
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/ICO.0000000000001799
dc.identifier.eissn1536-4798
dc.identifier.issn0277-3740
dc.identifier.pubmedidMEDLINE:30371569
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000001799
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78094
dc.identifier.wosidWOS:000467772400003
dc.information.autorucMedicina;Aravena C;S/I;120794
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final7
dc.pagina.inicio1
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaCORNEA
dc.rightsacceso restringido
dc.subjectlimbal stem cell deficiency
dc.subjectlimbal stem cell
dc.subjectclassification system
dc.subjectin vivo confocal microscopy
dc.subjectdiagnosis
dc.subjectMICROSCOPIC ANALYSIS
dc.subjectCORNEAL
dc.subjectEPITHELIUM
dc.subjectDIAGNOSIS
dc.subjectDENSITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClassification of Limbal Stem Cell Deficiency Using Clinical and Confocal Grading
dc.typeartículo
dc.volumen38
sipa.codpersvinculados120794
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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