BLOOD MARKERS IN ALZHEIMER-DISEASE - SUBNORMAL ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN LYMPHOCYTES AND ERYTHROCYTES

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dc.contributor.authorINESTROSA, NC
dc.contributor.authorALARCON, R
dc.contributor.authorARRIAGADA, J
dc.contributor.authorDONOSO, A
dc.contributor.authorALVAREZ, J
dc.contributor.authorCAMPOS, EO
dc.date.accessioned2024-01-10T12:37:50Z
dc.date.available2024-01-10T12:37:50Z
dc.date.issued1994
dc.description.abstractIn patients with the clinical diagnosis of Alzheimer disease (AD), we searched for systemic changes in components of the blood as a diagnostic tool. The acetylcholine-related enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were measured in plasma, erythrocytes, platelets and lymphocytes. Results did not show a general effect; notwithstanding, specific cell types presented alterations either in AChE or BuChE but not in both enzymatic activities. In AD patients, AChE of lymphocytes was reduced by 60% compared with the age-matched controls. However, when patients were divided, the sporadic but not the familial subgroup exhibited a significant reduction. In erythrocytes the BuChE activity was reduced by 45% in sporadic AD. The molecular forms of the lymphocyte AChE were characterized by velocity sedimentation. Both globular forms were subnormal, more so the tetrameric G(4) AChE form than the G(2) form.
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/0022-510X(94)90044-2
dc.identifier.issn0022-510X
dc.identifier.pubmedidMEDLINE:8195795
dc.identifier.urihttps://doi.org/10.1016/0022-510X(94)90044-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76934
dc.identifier.wosidWOS:A1994MZ29400001
dc.information.autorucActividades Universitarias;Alarcon R;S/I;109988
dc.information.autorucCiencias Biológicas;Alvarez J;S/I;98127
dc.information.autorucActividades Universitarias;Arriagada J;S/I;112853
dc.information.autorucCiencias Biológicas;Campos E;S/I;116025
dc.information.autorucCiencias Biológicas;Inestrosa N;S/I;99331
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final5
dc.pagina.inicio1
dc.publisherELSEVIER SCIENCE BV
dc.revistaJOURNAL OF THE NEUROLOGICAL SCIENCES
dc.rightsacceso restringido
dc.subjectCHOLINERGIC MARKERS
dc.subjectLYMPHOCYTES
dc.subjectERYTHROCYTES
dc.subjectPLATELETS
dc.subjectPLASMA
dc.subjectALZHEIMERS DISEASE
dc.subjectDIAGNOSTIC TEST
dc.subjectSENILE DEMENTIA
dc.subjectMOLECULAR-FORMS
dc.subjectPRECURSOR
dc.subjectDIAGNOSIS
dc.subjectPROTEIN
dc.subjectPLASMA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBLOOD MARKERS IN ALZHEIMER-DISEASE - SUBNORMAL ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE IN LYMPHOCYTES AND ERYTHROCYTES
dc.typeartículo
dc.volumen122
sipa.codpersvinculados109988
sipa.codpersvinculados98127
sipa.codpersvinculados112853
sipa.codpersvinculados116025
sipa.codpersvinculados99331
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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