Diffusible signal factor signaling controls bioleaching activity and niche protection in the acidophilic, mineral-oxidizing leptospirilli

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dc.contributor.authorBellenberg, Soren
dc.contributor.authorSalas, Beatriz
dc.contributor.authorGanji, Suresh
dc.contributor.authorJorquera-Roman, Cristian
dc.contributor.authorValenzuela, Maria Luisa
dc.contributor.authorBuetti-Dinh, Antoine
dc.contributor.authorUnelius, C. Rikard
dc.contributor.authorDopson, Mark
dc.contributor.authorVera, Mario
dc.date.accessioned2025-01-20T22:10:50Z
dc.date.available2025-01-20T22:10:50Z
dc.date.issued2021
dc.description.abstractBioleaching of metal sulfide ores involves acidophilic microbes that catalyze the chemical dissolution of the metal sulfide bond that is enhanced by attached and planktonic cell mediated oxidation of iron(II)-ions and inorganic sulfur compounds. Leptospirillum spp. often predominate in sulfide mineral-containing environments, including bioheaps for copper recovery from chalcopyrite, as they are effective primary mineral colonizers and oxidize iron(II)-ions efficiently. In this study, we demonstrated a functional diffusible signal factor interspecies quorum sensing signaling mechanism in Leptospirillum ferriphilum and Leptospirillum ferrooxidans that produces (Z)-11-methyl-2-dodecenoic acid when grown with pyrite as energy source. In addition, pure diffusible signal factor and extracts from supernatants of pyrite grown Leptospirillum spp. inhibited biological iron oxidation in various species, and that pyrite grown Leptospirillum cells were less affected than iron grown cells to self inhibition. Finally, transcriptional analyses for the inhibition of iron-grown L. ferriphilum cells due to diffusible signal factor was compared with the response to exposure of cells to N- acyl-homoserine-lactone type quorum sensing signal compounds. The data suggested that Leptospirillum spp. diffusible signal factor production is a strategy for niche protection and defense against other microbes and it is proposed that this may be exploited to inhibit unwanted acidophile species.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-021-95324-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-021-95324-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94390
dc.identifier.wosidWOS:000684343800009
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.titleDiffusible signal factor signaling controls bioleaching activity and niche protection in the acidophilic, mineral-oxidizing leptospirilli
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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