Oxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification

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dc.catalogadorgjm
dc.contributor.authorFuentes Lemus, Eduardo Felipe
dc.contributor.authorHägglund, Per
dc.contributor.authorLópez Alarcón, Camilo Ignacio
dc.contributor.authorDavies, Michael J.
dc.date.accessioned2024-12-30T19:14:22Z
dc.date.available2024-12-30T19:14:22Z
dc.date.issued2022
dc.description.abstractCovalent crosslinks within or between proteins play a key role in determining the structure and function of proteins. Some of these are formed intentionally by either enzymatic or molecular reactions and are critical to normal physiological function. Others are generated as a consequence of exposure to oxidants (radicals, excited states or two-electron species) and other endogenous or external stimuli, or as a result of the actions of a number of enzymes (e.g., oxidases and peroxidases). Increasing evidence indicates that the accumulation of unwanted crosslinks, as is seen in ageing and multiple pathologies, has adverse effects on biological function. In this article, we review the spectrum of crosslinks, both reducible and non-reducible, currently known to be formed on proteins; the mechanisms of their formation; and experimental approaches to the detection, identification and characterization of these species.
dc.description.funderEuropean Union
dc.description.funderNovo Nordisk Foundation
dc.description.funderCarlsberg Foundation
dc.description.funderFondecyt
dc.fechaingreso.objetodigital2024-12-30
dc.format.extent31 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3390/molecules27010015
dc.identifier.eissn1420-3049
dc.identifier.pubmedidMEDLINE:35011250
dc.identifier.urihttps://doi.org/10.3390/molecules27010015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89389
dc.identifier.wosidWOS:000751394200001
dc.information.autorucEscuela de Química; Fuentes Lemus, Eduardo Felipe; 0000-0002-1465-8466; 186720
dc.information.autorucEscuela de Química; López Alarcón, Camilo Ignacio; S/I; 1004308
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaMolecules
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCrosslink
dc.subjectDimerization
dc.subjectProtein oxidation
dc.subjectRadicals
dc.subjectDi-tyrosine
dc.subjectDi-tryptophan
dc.subjectDisulfides
dc.subjectThiols
dc.subjectAggregation
dc.subjectProteomics
dc.subjectMass spectrometry
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.titleOxidative Crosslinking of Peptides and Proteins: Mechanisms of Formation, Detection, Characterization and Quantification
dc.typeartículo
dc.volumen27
sipa.codpersvinculados186720
sipa.codpersvinculados1004308
sipa.trazabilidadWOS;18-03-2022
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