Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease

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dc.contributor.authorYounossi, Zobair M.
dc.contributor.authorStepanova, Maria
dc.contributor.authorOng, Janus
dc.contributor.authorYilmaz, Yusuf
dc.contributor.authorDuseja, Ajay
dc.contributor.authorEguchi, Yuichiro
dc.contributor.authorEl Kassas, Mohamed
dc.contributor.authorCastellanos-Fernandez, Marlen
dc.contributor.authorGeorge, Jacob
dc.contributor.authorJacobson, Ira M.
dc.contributor.authorBugianesi, Elisabetta
dc.contributor.authorWong, Vincent Wai-Sun
dc.contributor.authorArrese, Marco
dc.contributor.authorde Ledinghen, Victor
dc.contributor.authorRomero-Gomez, Manuel
dc.contributor.authorMendez-Sanchez, Nahum
dc.contributor.authorAhmed, Aijaz
dc.contributor.authorWong, Robert
dc.contributor.authorPapatheodoridis, Georgios
dc.contributor.authorSerfaty, Lawrence
dc.contributor.authorYounossi, Issah
dc.contributor.authorNader, Fatema
dc.contributor.authorZiayee, Mariam
dc.contributor.authorAfendy, Arian
dc.date.accessioned2025-01-23T21:12:35Z
dc.date.available2025-01-23T21:12:35Z
dc.date.issued2019
dc.description.abstractBACKGROUND & AIMS: Non-alcoholic and alcohol-related fatty liver disease are overlapping diseases in which metabolic syndrome and alcohol consumption each contribute to progressive liver disease. We aimed to assess the effects of alcohol consumption and metabolic syndrome on mortality in individuals with fatty liver.
dc.description.abstractMETHODS: We searched the National Health and Nutrition and Examination Survey III for adults (20-74 years old) with hepatic steatosis, detected by ultrasound, for whom mortality and follow-up data were available. We collected data from the alcohol use questionnaire (self-reported number of days a participant drank alcohol; the number of drinks [10 g alcohol] per day on a drinking day; the number of days the participant had 5 or more drinks) and calculated the average amount of alcohol consumption in drinks/day for each participant during the year preceding enrollment. Excessive alcohol consumption for men was >3 drinks/day and for women was >1.5 drinks/day. We also collected clinical data, and mortality data were obtained from the National Death Index. Demographic and clinical parameters were compared among consumption groups using the chi(2) test for independence or survey regression models. We used Cox proportional hazard models to identify independent predictors of all-cause and cause-specific mortality.
dc.description.abstractRESULTS: The study cohort included 4264 individuals with hepatic steatosis (mean age, 45.9 years; 51% male; 76% white; 46% with metabolic syndrome; 6.2% with excessive alcohol use). There was no significant difference in mean age between individuals with vs without excessive alcohol consumption (P=.65). However, overall mortality was significantly higher among participants with excessive alcohol consumption (32.2%) vs participants with non-excessive alcohol use (22.2%) after mean 20 years of follow up (P=.003), as well as after 5 years of follow up. In multivariate analysis, the presence of metabolic syndrome (adjusted hazard ratio [aHR], 1.43; 95% CI, 1.12-1.83) and excessive alcohol consumption (aHR, 1.79; 95% CI, 1.21-2.66) were independently associated with an increased risk of death in individuals with hepatic steatosis; any lower average amount of alcohol consumption was not associated with mortality (all P>.60). In a subgroup analysis, the association of excessive alcohol use with mortality was significant in individuals with metabolic syndrome (aHR, 2.46; 95% CI, 1.40-4.32) but not without it (P = .74).
dc.description.abstractCONCLUSION: In review of data from the National Health and Nutrition and Examination Survey III, we associated alcohol consumption with increased mortality in participants with fatty liver and metabolic syndrome. These findings indicate an overlap between non-alcoholic and alcohol-related fatty liver disease.
dc.description.funderGlobal NASH Council, Center for Outcomes Research in Liver Disease
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cgh.2018.11.033
dc.identifier.eissn1542-7714
dc.identifier.issn1542-3565
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2018.11.033
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100962
dc.identifier.wosidWOS:000471783300034
dc.issue.numero8
dc.language.isoen
dc.pagina.final+
dc.pagina.inicio1625
dc.revistaClinical gastroenterology and hepatology
dc.rightsacceso restringido
dc.subjectOutcomes
dc.subjectAlcohol Abuse
dc.subjectDiabetes
dc.subjectNASH
dc.subjectChronic Liver Disease
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease
dc.typeartículo
dc.volumen17
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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