Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of <i>Ugni molinae</i>

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dc.contributor.authorAguirre, Maria C.
dc.contributor.authorDelporte, Carla
dc.contributor.authorBackhouse, Nadine
dc.contributor.authorErazo, Silvia
dc.contributor.authorLetelier, Maria Eugenia
dc.contributor.authorCassels, Bruce K.
dc.contributor.authorSilva, Ximena
dc.contributor.authorAlegria, Sergio
dc.contributor.authorNegrete, Rosa
dc.date.accessioned2025-01-21T01:06:00Z
dc.date.available2025-01-21T01:06:00Z
dc.date.issued2006
dc.description.abstractLeaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2 alpha-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. (c) 2006 Elsevier Ltd. All rights reserved.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bmc.2006.04.021
dc.identifier.eissn1464-3391
dc.identifier.issn0968-0896
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2006.04.021
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96065
dc.identifier.wosidWOS:000239472700027
dc.issue.numero16
dc.language.isoen
dc.pagina.final5677
dc.pagina.inicio5673
dc.revistaBioorganic & medicinal chemistry
dc.rightsacceso restringido
dc.subjectUgni molinae
dc.subjectasiatic acid
dc.subjectcorosolic acid
dc.subjectalphitolic acid
dc.subjectanti-inflammatory activity-triterpenoids
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTopical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of <i>Ugni molinae</i>
dc.typeartículo
dc.volumen14
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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