A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers

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dc.contributor.authorCuevas, AM
dc.contributor.authorGuasch, V
dc.contributor.authorCastillo, O
dc.contributor.authorIrribarra, V
dc.contributor.authorMizon, C
dc.contributor.authorSan Martin, A
dc.contributor.authorStrobel, P
dc.contributor.authorPerez, D
dc.contributor.authorGermain, AM
dc.contributor.authorLeighton, F
dc.date.accessioned2025-01-21T01:31:34Z
dc.date.available2025-01-21T01:31:34Z
dc.date.issued2000
dc.description.abstractEndothelial dysfunction is associated with atherogenesis and oxidative stress in humans. In rat and rabbit blood vessels, wine polyphenol antioxidants induce vascular relaxation in vitro through the NO-cCMP pathway. To assess the effect of a regular high-fat diet (HFD) and moderate red wine consumption on endothelial function (EF), a study was performed in healthy male volunteers. EF was measured as flow-mediated dilatation of the brachial artery, employing high-resolution ultrasound after an overnight fast. Other clinical and biochemical parameters related to EF were also measured. Six volunteers received a control diet, rich in fruits and vegetables (27% calories as fat) and five volunteers received an HFD (39.5% calories as fat). Measurements were done twice on each volunteer: after a period of 30 d with diet plus 240 mt of red wine/d, and after a period of 30 d with diet, without wine. In the absence of wine, there is a reduction of EF with HFD when compared to the control diet (P = 0.014). This loss of EF is not seen when both diets are supplemented with wine for 30 d (P = 0.001). Plasma levels of n-3 fatty acids (R-2 = 0.232, P = 0.023) and lycopene (R-2 = 0.223, P = 0.020) show a positive correlation with individual EF measurements, but they do not account for the significant differences observed among dietary groups or after wine supplementation. These results help elucidate the deleterious effect of a high-fat diet and the protective role of wine, n-3 fatty acids and dietary antioxidants in cardiovascular disease.
dc.fuente.origenWOS
dc.identifier.eissn1558-9307
dc.identifier.issn0024-4201
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97096
dc.identifier.wosidWOS:000086099500004
dc.issue.numero2
dc.language.isoen
dc.pagina.final148
dc.pagina.inicio143
dc.revistaLipids
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers
dc.typeartículo
dc.volumen35
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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