Human development, inequality, and their associations with brain structure across 29 countries

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dc.article.number1572318
dc.catalogadorcarga
dc.contributor.authorMedel, V.
dc.contributor.authorAlliende, L.M.
dc.contributor.authorBethlehem, R.
dc.contributor.authorSeidlitz, J.
dc.contributor.authorRinglein, G.
dc.contributor.authorArango, C.
dc.contributor.authorArnatkeviciute, A.
dc.contributor.authorAsmal, L.
dc.contributor.authorBellgrove, M.
dc.contributor.authorBenegal, V.
dc.contributor.authorBernardo, M.
dc.contributor.authorBilleke, P.
dc.contributor.authorBosch-Bayard, J.
dc.contributor.authorBressan, R.
dc.contributor.authorBusatto, G.
dc.contributor.authorCastro, M.
dc.contributor.authorChaim-Avancini, T.
dc.contributor.authorCostanzi, M.
dc.contributor.authorCzepielewski, L.
dc.contributor.authorDazzan, P.
dc.contributor.authorde la Fuente-Sandoval, C.
dc.contributor.authorDiaz-Caneja, C.M.
dc.contributor.authorDiaz-Zuluaga, A.M.
dc.contributor.authorPlessis, S.D.
dc.contributor.authorDuran, F.
dc.contributor.authorFittipaldi, S.
dc.contributor.authorFornito, A.
dc.contributor.authorFreimer, N.
dc.contributor.authorGadelha, A.
dc.contributor.authorGama, C.
dc.contributor.authorGarani, R.
dc.contributor.authorGarcia-Rizo, C.
dc.contributor.authorCampo, C.G.
dc.contributor.authorGonzalez-Valderrama, A.
dc.contributor.authorGuinjoan, S.
dc.contributor.authorHolla, B.
dc.contributor.authorIbanez, A.
dc.contributor.authorIvanovic, D.
dc.contributor.authorJackowski, A.
dc.contributor.authorLeon-Ortiz, P.
dc.contributor.authorLochner, C.
dc.contributor.authorLopez-Jaramillo, C.
dc.contributor.authorLuckhoff, H.
dc.contributor.authorMassuda, R.
dc.contributor.authorMcGuire, P.
dc.contributor.authorMiyata, J.
dc.contributor.authorMizrahi, R.
dc.contributor.authorMurray, R.
dc.contributor.authorOzerdem, A.
dc.contributor.authorPan, P.
dc.contributor.authorParellada, M.
dc.contributor.authorPhahladira, L.
dc.contributor.authorRamirez-Mahaluf, J.P.
dc.contributor.authorReckziegel, R.
dc.contributor.authorMarques, T.R.
dc.contributor.authorReyes-Madrigal, F.
dc.contributor.authorRoos, A.
dc.contributor.authorRosa, P.
dc.contributor.authorSalum, G.
dc.contributor.authorScheffler, F.
dc.contributor.authorSchumann, G.
dc.contributor.authorSerpa, M.
dc.contributor.authorStein, D.J.
dc.contributor.authorTepper, A.
dc.contributor.authorTiego, J.
dc.contributor.authorUeno, T.
dc.contributor.authorUndurraga, J.
dc.contributor.authorUndurraga, Eduardo A.
dc.contributor.authorValdes-Sosa, P.
dc.contributor.authorValli, I.
dc.contributor.authorVillarreal, M.
dc.contributor.authorWinton-Brown, T.
dc.contributor.authorYalin, N.
dc.contributor.authorZamorano, F.
dc.contributor.authorZanetti, M.
dc.contributor.authorWinkler, A.
dc.contributor.authorEvans-Lacko, S.
dc.contributor.authorForti, M.D.
dc.contributor.authorCrossley, N.A.
dc.date.accessioned2025-08-30T11:01:46Z
dc.date.available2025-08-30T11:01:46Z
dc.date.issued2025
dc.description.abstract© 2025 Cambridge University Press. All rights reserved.Background: The macro-social and environmental conditions in which people live, such as the level of a country’s development or inequality, are associated with brain-related disorders. However, the relationship between these systemic environmental factors and the brain remains unclear. We here aimed to determine the association between the level of development and inequality of a country and the brain structure of healthy adults. Methods: We conducted a cross-sectional study pooling brain imaging (T1-based) data from 145 magnetic resonance imaging (MRI) studies in 7,962 healthy adults (4,110 women) in 29 different countries. We used a meta-regression approach to relate the brain structure with the country’s level of development and inequality. Results: Higher human development was consistently associated with larger hippocampi and more expanded global cortical surface area, particularly in frontal areas. Increased inequality was most consistently associated with smaller hippocampal volume and thinner cortical thickness across the brain. Conclusions: Our results suggest that the macro-economic conditions of a country are reflected in its inhabitants’ brains and may explain the different incidence of brain disorders across the world. The observed variability of brain structure in health across countries should be considered when developing tools in the field of personalized or precision medicine that are intended to be used across the world.
dc.description.funderFONDECYT; Folios: 1250261, 1250252
dc.fechaingreso.objetodigital2025-09-08
dc.format.extent13 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1192/j.eurpsy.2025.10060
dc.identifier.eissn1550-9613
dc.identifier.issn17783585 09249338
dc.identifier.scopusidSCOPUS_ID:105010933575
dc.identifier.urihttps://doi.org/10.1192/j.eurpsy.2025.10060
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105482
dc.identifier.wosidWOS:001510704800001
dc.information.autorucNo Informado; Undurraga Fourcade, Eduardo Andres; S/I; 12868
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final13
dc.pagina.inicio1
dc.publisherCambridge University Press
dc.relation.ispartof21st Annual Conference of the International-Society-for-Environmental-Epidemiology, AUG 25-29, 2009, Dublin, IRELAND
dc.revistaEuropean Psychiatry
dc.rightsacceso abierto
dc.subjectbrain structure
dc.subjectinequality
dc.subjectmeta-regression
dc.subjectMRI
dc.subjectpoverty
dc.subjectSocial determinants of health
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHuman development, inequality, and their associations with brain structure across 29 countries
dc.typeartículo
dc.volumen68
sipa.codpersvinculados12868
sipa.indexScopus
sipa.trazabilidadWOS-SCOPUS;2025-08-30
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