Risk factors for adverse drug reactions in patients admitted to intensive care unitsDeterminación de factores de riesgo a reacciones adversas a medicamentos mediante farmacovigilancia intensiva en UCI

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dc.article.number877209
dc.contributor.authorObreque K.
dc.contributor.authorMellado R.
dc.contributor.authorAndresen M.
dc.date.accessioned2025-05-01T10:32:40Z
dc.date.available2025-05-01T10:32:40Z
dc.date.issued2021
dc.description.abstract© 2021 Sociedad Medica de Santiago. All rights reserved.Background: Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR). Aim: To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU. Patients and Methods: An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR. Results: Eighty-five patients were surveilled and 24 (28%) had an ADR. A total of 48 drugs responsible for at least one ADR were identified. Seventy-three percent ADR were moderate and 27% were severe. The clinical variables significantly associated with ADR were a history of allergies, a high body mass index, the reason for admission, an APACHE II score ≥ 14 points, the use of invasive mechanical ventilation and more than seven days of hospitalization. The pharmacological variables associated with ADR were polypharmacy and medication associations and combinations. Conclusions: The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR.
dc.description.funderEPSRC
dc.description.funderFONDECYT
dc.description.funderFoundation for the Advancement of Theoretical Physics and Mathematics
dc.format.extent1266 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/S0034-98872021000901258
dc.identifier.eisbn978-1-0716-1534-8
dc.identifier.eissn7176163
dc.identifier.isbn978-1-0716-1533-1
dc.identifier.issn349887
dc.identifier.pubmedid35319678
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85126894492
dc.identifier.urihttps://doi.org/10.4067/S0034-98872021000901258
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103883
dc.identifier.wosidWOS:001072643600005
dc.information.autorucEscuela de Medicina; Andresen Hernandez Max Alfonso; 0000-0003-1874-1416; 54274
dc.information.autorucESCUELA QUÍMICA Y FARMACIA; Mellado Suazo Rosemarie; 0000-0002-9569-5057; 109357
dc.issue.numero9
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1266
dc.pagina.inicio1258
dc.publisherHUMANA PRESS INC
dc.relation.ispartofRevista Medica de Chile
dc.revistaRevista Medica de Chile
dc.rightsAcceso abierto
dc.subjectDrug Interactions
dc.subjectDrug-Related Side Effects and Adverse Reactions
dc.subjectPolypharmacy)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRisk factors for adverse drug reactions in patients admitted to intensive care unitsDeterminación de factores de riesgo a reacciones adversas a medicamentos mediante farmacovigilancia intensiva en UCI
dc.typeartículo
dc.volumen149
sipa.codpersvinculados54274
sipa.codpersvinculados109357
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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