Exercise training reduces brainstem oxidative stress and restores normal breathing function in heart failure

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dc.contributor.authorDiaz-Jara, Esteban
dc.contributor.authorDiaz, Hugo S.
dc.contributor.authorRios-Gallardo, Angelica
dc.contributor.authorOrtolani, Domiziana
dc.contributor.authorAndrade, David C.
dc.contributor.authorToledo, Camilo
dc.contributor.authorV. Pereyra, Katherin
dc.contributor.authorSchwarz, Karla
dc.contributor.authorRamirez, Gigliola
dc.contributor.authorOrtiz, Fernando C.
dc.contributor.authorAndia, Marcelo E.
dc.contributor.authorDel Rio, Rodrigo
dc.date.accessioned2025-01-20T22:10:49Z
dc.date.available2025-01-20T22:10:49Z
dc.date.issued2021
dc.description.abstractEnhanced central chemoreflex drive and irregular breathing are both hallmarks in heart failure (HF) and closely related to disease progression. Central chemoreceptor neurons located within the retrotrapezoid nucleus (RTN) are known to play a role in breathing alterations in HF. It has been shown that exercise (EX) effectively reduced reactive oxygen species (ROS) in HF rats. However, the link between EX and ROS, particularly at the RTN, with breathing alterations in HF has not been previously addressed. Accordingly, we aimed to determine: i) ROS levels in the RTN in HF and its association with chemoreflex drive, ii) whether EX improves chemoreflex/breathing function by reducing ROS levels, and iii) determine molecular alterations associated with ROS generation within the RTN of HF rats and study EX effects on these pathways. Adult male Sprague-Dawley rats were allocated into 3 experimental groups: Sham (n = 5), volume overloaded HF (n = 6) and HF (n = 8) rats that underwent EX training for 6 weeks (60 min/day, 25 m/min, 10% inclination). At 8 weeks post-HF induction, breathing patterns and chemoreflex function were analyzed by unrestrained plethysmography. ROS levels and anti/pro-oxidant enzymes gene expression were analyzed in the RTN. Our results showed that HF rats have high ROS levels in the RTN which were closely linked to the enhanced central chemoreflex and breathing disorders. Also, HF rats displayed decreased expression of antioxidant genes in the RTN compared with control rats. EX training increases antioxidant defense in the RTN, reduces ROS formation and restores normal central chemoreflex drive and breathing regularity in HF rats. This study provides evidence for a role of ROS in central chemoreception in the setting of HF and support the use of EX to reduce ROS in the brainstem of HF animals and reveal its potential as an effective mean to normalize chemoreflex and breathing function in HF.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.freeradbiomed.2021.06.032
dc.identifier.eissn1873-4596
dc.identifier.issn0891-5849
dc.identifier.urihttps://doi.org/10.1016/j.freeradbiomed.2021.06.032
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94389
dc.identifier.wosidWOS:000685094200005
dc.language.isoen
dc.pagina.final481
dc.pagina.inicio470
dc.revistaFree radical biology and medicine
dc.rightsacceso restringido
dc.subjectOxidative stress
dc.subjectCentral chemoreflex
dc.subjectRetrotrapezoid nucleus
dc.subjectExercise training
dc.subjectHeart failure
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExercise training reduces brainstem oxidative stress and restores normal breathing function in heart failure
dc.typeartículo
dc.volumen172
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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