Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?

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dc.contributor.authorGuerrero-Bosagna, C
dc.contributor.authorSabat, P
dc.contributor.authorValladares, L
dc.date.accessioned2025-01-21T01:06:51Z
dc.date.available2025-01-21T01:06:51Z
dc.date.issued2005
dc.description.abstractDNA methylation is one of the epigenetic and hereditary mechanisms regulating genetic expression in mammalian cells. In this review, we propose how certain natural agents, through their dietary consumption, could induce changes in physiological aspects in mammalian mothers, leading to alterations in DNA methylation patterns of the developing fetus and to the emergence of new phenotypes and evolutionary change. Nevertheless, we hypothesize that this process would require (i) certain key periods in the ontogeny of the organism where the environmental stimuli could produce effects, (ii) particular environmental agents as such stimuli, and (iii) that a genomic persistent change be consequently produced in a population. Depending on the persistence of the environmental stimuli and on whether the affected genes are imprinted genes, induced changes in DNA methylation patterns could become persistent. Moreover, some fragments could be more frequently methylated than others over several generations, leading to biased base change and evolutionary consequences.
dc.fuente.origenWOS
dc.identifier.eissn1525-142X
dc.identifier.issn1520-541X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96233
dc.identifier.wosidWOS:000230054900010
dc.issue.numero4
dc.language.isoen
dc.pagina.final350
dc.pagina.inicio341
dc.revistaEvolution & development
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEnvironmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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