DECREASED PLATELET COUNTS AND DECREASED PLATELET SEROTONIN IN POSTSTREPTOCOCCAL NEPHRITIS

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dc.contributor.authorMEZZANO, S
dc.contributor.authorKUNICK, M
dc.contributor.authorOLAVARRIA, F
dc.contributor.authorARDILES, L
dc.contributor.authorARANDA, E
dc.contributor.authorMEZZANO, D
dc.date.accessioned2024-01-10T13:12:10Z
dc.date.available2024-01-10T13:12:10Z
dc.date.issued1995
dc.description.abstractMean platelet survival time in patients with acute poststreptococcal glomerulo-nephritis (APSGN) is reduced to 50-60% of the control values, and glomerular deposits of platelet factor 4 are found in these patients. In order to investigate further systemic platelet changes of pathogenic, clinical or prognostic significance, we measured the platelet serotonin (5-HT) content and the blood platelet counts during the Ist week of the disease in 27 patients with APSGN. Platelet 5-HT was significantly reduced in patients with APSGN as compared with patients with impetigo without glomerular involvement (785+/-54 vs. 1,329+/-94 ng 5-HT/10(9) platelets; p<0.001). Similarly, the mean blood platelet count was reduced to 247+/-16x10(3) as compared with 303+/-14x10(3) in the controls (p<0.05). Thirteen (48%) of these patients had individual values of platelet 5-HT lower than the 95% confidence interval calculated in the control group. No significant correlation was observed between the concentration of 5-HT and either the severity of the disease judged by the amount of urinary protein excretion and the serum creatinine value or the presence of circulating immune complexes. Significant correction of the platelet 5-HT content (to 1,180+/-111 ng/10(9) platelets; p<0.01) and of the platelet counts (to 309+/-21x10(3); p<0.01) were observed in the longitudinal study at least 2 weeks later. Platelet activation, with secretion of granular content and increased consumption, may explain these findings. Additionally, the reduced mean age of the circulating platelets could contribute to their decreased 5-HT levels. The reduced platelet counts are not of clinical significance, but serial measurements of platelet 5-HT may be useful in predicting active glomerular inflammation.
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1159/000188428
dc.identifier.eissn2235-3186
dc.identifier.issn1660-8151
dc.identifier.pubmedidMEDLINE:7723894
dc.identifier.urihttps://doi.org/10.1159/000188428
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78149
dc.identifier.wosidWOS:A1995QE46200003
dc.information.autorucMedicina;Mezzano D;S/I;99455
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final139
dc.pagina.inicio135
dc.publisherKARGER
dc.revistaNEPHRON
dc.rightsacceso restringido
dc.subjectPOSTSTREPTOCOCCAL GLOMERULONEPHRITIS
dc.subjectNEPHRITIC SYNDROME
dc.subjectPLATELET
dc.subjectSEROTONIN
dc.subjectIMMUNE COMPLEXES
dc.subjectIMMUNE-COMPLEX NEPHRITIS
dc.subjectPLASMA SEROTONIN
dc.subjectSTREPTOCOCCAL NEPHRITIS
dc.subjectINTRAPLATELET SEROTONIN
dc.subjectGLOMERULAR INJURY
dc.subjectSYSTEMIC LUPUS
dc.subjectGLOMERULONEPHRITIS
dc.subjectLOCALIZATION
dc.subjectDISEASE
dc.subjectDENSITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDECREASED PLATELET COUNTS AND DECREASED PLATELET SEROTONIN IN POSTSTREPTOCOCCAL NEPHRITIS
dc.typeartículo
dc.volumen69
sipa.codpersvinculados99455
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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