Cerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve

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dc.contributor.authorNien, JK
dc.contributor.authorSchmidt, J
dc.contributor.authorCartier, L
dc.contributor.authorAlvarez, J
dc.date.accessioned2025-01-21T01:32:35Z
dc.date.available2025-01-21T01:32:35Z
dc.date.issued1998
dc.description.abstractHTLV-1 (human T-cell leukemia virus type I) associated myelopathy (HAM) is a demyelinating disease. We showed that the CSF of patients and heated CSF of normal subjects induce a segmentary demyelination in rat nerves, and potentiate trypsin in vitro. Here we further characterize the neuropathy induced by the CSF of patients. Peroneal nerves injected 5-8 days before with native or heated CSF of patients, besides extensive demyelination, presented proliferation of myelinating and nonmyelinating Schwann cells, axonal sprouting, fine fibres with a few turns of myelin, disarray of nonmedullated bundles, desmosome-like junctions, and coated pits and vesicles in Schwann cells and axons. The normal CSF was innocuous to the nerve in its native form, but after heating, it induced a neuropathy in all, similar to that elicited by the CSF of patients. Our findings indicate that the CSF of HAM patients contains a thermostable pathogen for nerves of the rat; a thermostable pathogen also occurs in the normal CSF although its activity is checked by endogenous thermolabile factors. We suggest that the pathogen present in the CSF of HAM patients participates in the disease. (C) 1998 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.issn0022-510X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97288
dc.identifier.wosidWOS:000075084500003
dc.issue.numero1
dc.language.isoen
dc.pagina.final24
dc.pagina.inicio17
dc.revistaJournal of the neurological sciences
dc.rightsacceso restringido
dc.subjectCSF
dc.subjectHAM
dc.subjecttropical spastic paraparesis
dc.subjectdemyelination
dc.subjectprotease
dc.subjectproliferation
dc.subjectglia
dc.subjectSchwann
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCerebrospinal fluid of HTLV-1 associated myelopathy patients induces axonal sproutings and Schwann cell proliferation in the rat sciatic nerve
dc.typeartículo
dc.volumen159
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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