Laryngeal Mucous Membrane Pemphigoid as an Immune-related Adverse Effect of Pembrolizumab Treatment

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dc.catalogadordfo
dc.contributor.authorLagos Villaseca, Antonia Elisa
dc.contributor.authorKoshkin, Vadim S.
dc.contributor.authorKinet, Maxime J.
dc.contributor.authorRosen, Clark A.
dc.date.accessioned2024-06-05T19:55:09Z
dc.date.available2024-06-05T19:55:09Z
dc.date.issued2023
dc.description.abstractPembrolizumab is an immune checkpoint inhibitor (ICI) approved for multiple indications in a variety of malignancies. Although generally well tolerated, the potential for significant adverse effects, specifically immune related adverse effects (irAEs) needs to be taken into consideration. Several cases of bullous pemphigoid have been reported as a cutaneous adverse effect of ICIs since 2015, and there are recent reports of mucous membrane pemphigoid (MMP). We present the case of an 84-year-old male with metastatic urothelial carcinoma on treatment with pembrolizumab, who developed laryngeal mucous membrane pemphigoid as an irAE. The diagnosis was based on patient's clinical history and serologic testing, and supported by symptomatic improvement after ICI discontinuation and immunosuppression. Pembrolizumab-induced MMP is a newly described and infrequent irAE, requiring early suspicion and close monitoring for its diagnosis and management
dc.fechaingreso.objetodigital2024-09-02
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jvoice.2022.12.028
dc.identifier.eissn1873-4588
dc.identifier.issn0892-1997
dc.identifier.urihttps://doi.org/10.1016/j.jvoice.2022.12.028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86470
dc.information.autorucEscuela de Medicina; Lagos Villaseca, Antonia Elisa; 0000-0002-2579-5474; 185024
dc.language.isoen
dc.nota.accesoContenido parcial
dc.publisherElsevier
dc.revistaJournal of Voice
dc.rightsacceso restringido
dc.subjectLaryngitis
dc.subjectBenign mucous membrane pemphigoidImmune-related adverse effect
dc.subjectImmune checkpoint inhibitors
dc.subjectPembrolizumab
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLaryngeal Mucous Membrane Pemphigoid as an Immune-related Adverse Effect of Pembrolizumab Treatment
dc.typecorrigendum
sipa.codpersvinculados185024
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