The 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA

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dc.contributor.authorVera Otarola, Jorge
dc.contributor.authorSoto Rifo, Ricardo
dc.contributor.authorRicci, Emiliano P.
dc.contributor.authorOhlmann, Theophile
dc.contributor.authorDarlix, Jean Luc
dc.contributor.authorLopez Lastra, Marcelo
dc.date.accessioned2024-01-10T12:09:16Z
dc.date.available2024-01-10T12:09:16Z
dc.date.issued2010
dc.description.abstractIn the process of translation of eukaryotic mRNAs, the 5' cap and the 3' poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of the Bunyaviridae, lacks a 3' poly(A) tail. Here we report that the 3' untranslated region (3'UTR) of the ANDV SmRNA functionally replaces a poly(A) tail and synergistically stimulates cap-dependent translation initiation from the viral mRNA. Stimulation of translation by the 3'UTR of the ANDV SmRNA was found to be independent of viral proteins and of host poly(A)-binding protein.
dc.description.funderProyecto Nucleo Milenio
dc.description.funderFONDECYT
dc.description.funderMECESUP-USACH
dc.description.funderFondation pour la Recherche Medicale (FRM)
dc.description.funderFrench Ministry (MENRT)
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1128/JVI.01270-10
dc.identifier.eissn1098-5514
dc.identifier.issn0022-538X
dc.identifier.pubmedidMEDLINE:20660206
dc.identifier.urihttps://doi.org/10.1128/JVI.01270-10
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76474
dc.identifier.wosidWOS:000282641800073
dc.information.autorucMedicina;López-Lastra M;S/I;84823
dc.issue.numero19
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final10424
dc.pagina.inicio10420
dc.publisherAMER SOC MICROBIOLOGY
dc.revistaJOURNAL OF VIROLOGY
dc.rightsacceso restringido
dc.subjectPOLY(A)-BINDING PROTEIN
dc.subjectINDEPENDENT TRANSLATION
dc.subjectPROTEOLYTIC CLEAVAGE
dc.subjectNUCLEOCAPSID PROTEIN
dc.subjectVIRUS
dc.subjectBINDING
dc.subjectEIF4GI
dc.subjectCELLS
dc.subjectIDENTIFICATION
dc.subjectREPLICATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe 3 ' Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
dc.typeartículo
dc.volumen84
sipa.codpersvinculados84823
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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