ANTIHYPERTENSIVE AND HORMONAL EFFECTS OF SINGLE ORAL DOSES OF CAPTOPRIL AND NIFEDIPINE IN ESSENTIAL-HYPERTENSION

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dc.contributor.authorSOTO, ME
dc.contributor.authorTHIBONNIER, M
dc.contributor.authorSIRE, O
dc.contributor.authorMENARD, J
dc.contributor.authorCORVOL, P
dc.contributor.authorMILLIEZ, P
dc.date.accessioned2025-01-23T19:44:12Z
dc.date.available2025-01-23T19:44:12Z
dc.date.issued1981
dc.description.abstractIn a single-dose crossover study captopril (SQ 14225), 1 mg/kg body wt, and nifedipine (Bay-a 1040) 20 mg were administered orally to 12 hospitalized patients with essential hypertension (stage 1 or 2, WHO). Both drugs significantly reduced blood pressure, but each dose acted differently: the mean maximum arterial pressure reduction was faster and greater with nifedipine than with captopril: -23 .+-. 2% at 37 .+-. 15 min and -17 .+-. 1% at 86 .+-. 25 min, respectively. Captopril inhibited angiotensin II and aldosterone production, but did not accelerate heart rate or stimulate vasopressin release. Nifedipine stimulated vasopressin release and increased heart rate, but the renin-angiotensin-aldosterone system was not significantly affected. The blood pressure reduction was related to the initial level of activation of the renin-angiotensin system only for captopril. The blood pressure reduction induced by 1 drug was not related to that produced by the other in the same patient.
dc.fuente.origenWOS
dc.identifier.eissn1432-1041
dc.identifier.issn0031-6970
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99975
dc.identifier.wosidWOS:A1981ME27600001
dc.issue.numero3
dc.language.isoen
dc.pagina.final161
dc.pagina.inicio157
dc.revistaEuropean journal of clinical pharmacology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleANTIHYPERTENSIVE AND HORMONAL EFFECTS OF SINGLE ORAL DOSES OF CAPTOPRIL AND NIFEDIPINE IN ESSENTIAL-HYPERTENSION
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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