Female offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8<SUP>+</SUP> T lymphocytes

Simple item page
dc.contributor.authorFunes, Samanta C.
dc.contributor.authorRios, Mariana
dc.contributor.authorFernandez-Fierro, Ayleen
dc.contributor.authorRivera-Perez, Daniela
dc.contributor.authorSoto, Jorge A.
dc.contributor.authorValbuena, Jose R.
dc.contributor.authorAltamirano-Lagos, Maria J.
dc.contributor.authorGomez-Santander, Felipe
dc.contributor.authorJara, Evelyn L.
dc.contributor.authorZoroquiain, Pablo
dc.contributor.authorRoa, Juan C.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorRiedel, Claudia A.
dc.date.accessioned2025-01-20T21:02:29Z
dc.date.available2025-01-20T21:02:29Z
dc.date.issued2022
dc.description.abstractMaternal thyroid hormones (THs) are essential for the appropriate development of the fetus and especially for the brain. Recently, some studies have shown that THs deficiency can also alter the immune system development of the progeny and their ability to mount an appropriate response against infectious agents. In this study, we evaluated whether adult mice gestated under hypothyroxinemia (Hpx) showed an altered immune response against infection with human metapneumovirus (hMPV). We observed that female mice gestated under Hpx showed higher clinical scores after seven days of hMPV infection. Besides, males gestated under Hpx have higher lung viral loads at day seven post-infection. Furthermore, the female offspring gestated in Hpx have already reduced the viral load at day seven and accordingly showed an increased proportion of activated (CD71(+) and FasL(+)) CD8(+) T cells in the lungs, which correlated with a trend for a higher histopathological clinical score. These results support that T-4 deficiency during gestation might condition the offspring differently in males and females, enhancing their ability to respond to hMPV.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fimmu.2022.966917
dc.identifier.issn1664-3224
dc.identifier.urihttps://doi.org/10.3389/fimmu.2022.966917
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93044
dc.identifier.wosidWOS:000859825900001
dc.language.isoen
dc.revistaFrontiers in immunology
dc.rightsacceso restringido
dc.subjectthyroid hormones
dc.subjectgestational hypothyroxinemia
dc.subjecthuman metapneumovirus (hMPV)
dc.subjectviral infection
dc.subjectmetapneumo virus
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFemale offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8<SUP>+</SUP> T lymphocytes
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas