Prophages carrying Zot toxins on different <i>Vibrio</i> genomes: A comprehensive assessment using multilayer networks

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dc.contributor.authorSoto, Esteban F.
dc.contributor.authorAlegria, Melissa
dc.contributor.authorSepulveda, Felipe
dc.contributor.authorGarcia, Katherine
dc.contributor.authorHiguera, Gaston
dc.contributor.authorCastillo, Daniel
dc.contributor.authorFonturbel, Francisco E.
dc.contributor.authorBastias, Roberto
dc.date.accessioned2025-01-20T16:17:44Z
dc.date.available2025-01-20T16:17:44Z
dc.date.issued2024
dc.description.abstractVibrios, a group of bacteria that are among the most abundant in marine environments, include several species such as Vibrio cholerae and Vibrio parahaemolyticus, which can be pathogenic to humans. Some species of Vibrio contain prophages within their genomes. These prophages can carry genes that code for toxins, such as the zonula occludens toxin (Zot), which contribute to bacterial virulence. Understanding the association between different Vibrio species, prophages and Zot genes can provide insights into their ecological interactions. In this study, we evaluated 4619 Vibrio genomes from 127 species to detect the presence of prophages carrying the Zot toxin. We found 2030 potential prophages with zot-like genes in 43 Vibrio species, showing a non-random association within a primarily modular interaction network. Some prophages, such as CTX or Vf33, were associated with specific species. In contrast, prophages phiVCY and VfO3K6 were found in 28 and 20 Vibrio species, respectively. We also identified six clusters of Zot-like sequences in prophages, with the ZOT2 cluster being the most frequent, present in 34 Vibrio species. This analysis helps to understand the distribution patterns of zot-containing prophages across Vibrio genomes and the potential routes of Zot-like toxin dissemination.
dc.description.funderFONDECYT
dc.fuente.origenWOS
dc.identifier.doi10.1111/1462-2920.16654
dc.identifier.eissn1462-2920
dc.identifier.issn1462-2912
dc.identifier.urihttps://doi.org/10.1111/1462-2920.16654
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90612
dc.identifier.wosidWOS:001229204100001
dc.issue.numero5
dc.language.isoen
dc.revistaEnvironmental microbiology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProphages carrying Zot toxins on different <i>Vibrio</i> genomes: A comprehensive assessment using multilayer networks
dc.typeartículo
dc.volumen26
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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