Biohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications

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dc.contributor.authorAgubata, Chukwuma O.
dc.contributor.authorMbaoji, Cynthia C.
dc.contributor.authorNzekwe, Ifeanyi T.
dc.contributor.authorSaldias, Cesar
dc.contributor.authorDiaz Diaz, David
dc.date.accessioned2025-01-20T22:11:58Z
dc.date.available2025-01-20T22:11:58Z
dc.date.issued2021
dc.description.abstractIn this work, a biohydrogel based on alginate and dynamic covalent B-O bonds, and derived composites, has been evaluated for wound healing applications. In particular, a phenylboronic acid-alginate (PBA-Alg) complex was synthesized by coupling 3-aminophenylboronic acid onto alginate, and used to prepare varied concentrations of hydrogels and silicate-based nanocomposites in PBS. The resulting hydrogels were characterized in terms of interfacial tension, moisture uptake and loss, interaction with fresh acid-soluble collagen, self-healing ability, effects on blood clotting and wound healing. The interfacial tension between the hydrogels and biorelevant fluids was low and moisture loss of 55-60% was evident without uptake from the environment. The components of the hydrogels and their mixtures with collagen were found to be compatible. These hydrogels showed efficient self-healing and thixotropic behavior, and the animals in the treatment groups displayed blood clotting times between 9.1 min and 10.7 min. In contrast, the composites showed much longer or shorter clotting times depending on the silicate content. A significant improvement in wound healing was observed in 3% w/v PBA-Alg formulations. Overall, the PBA-Alg hydrogels exhibit self-healing dynamic covalent interactions and may be useful in dressings for incision wounds.
dc.description.funderSpanish Ministry of Science and Innovation
dc.fuente.origenWOS
dc.identifier.doi10.3390/app11156945
dc.identifier.eissn2076-3417
dc.identifier.urihttps://doi.org/10.3390/app11156945
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94422
dc.identifier.wosidWOS:000681996300001
dc.issue.numero15
dc.language.isoen
dc.revistaApplied sciences-basel
dc.rightsacceso restringido
dc.subjectdynamic covalent bond
dc.subjectboron
dc.subjecthydrogel
dc.subjectalginate
dc.subjectself-healing
dc.subjectnanocomposite
dc.subjectblood clotting
dc.subjectwound healing
dc.titleBiohydrogel Based on Dynamic Covalent Bonds for Wound Healing Applications
dc.typeartículo
dc.volumen11
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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