Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study

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dc.contributor.authorPerez-Recio, Sandra
dc.contributor.authorPallares, Natalia
dc.contributor.authorGrijota-Camino, Maria D.
dc.contributor.authorSanchez-Montalva, Adrian
dc.contributor.authorBarcia, Laura
dc.contributor.authorCampos-Gutierrez, Silvia
dc.contributor.authorPomar, Virginia
dc.contributor.authorRabunal-Rey, Ramon
dc.contributor.authorBalcells, Maria Elvira
dc.contributor.authorGazel, Deniz
dc.contributor.authorMontiel, Natalia
dc.contributor.authorVicente, Diego
dc.contributor.authorGoic-Barisic, Ivana
dc.contributor.authorSchon, Thomas
dc.contributor.authorPaues, Jakob
dc.contributor.authorMarekovic, Ivana
dc.contributor.authorCacho-Calvo, Juana
dc.contributor.authorBarac, Aleksandra
dc.contributor.authorGoletti, Delia
dc.contributor.authorGarcia-Gasalla, Mercedes
dc.contributor.authorMaria Barcala, Jose
dc.contributor.authorTeresa Tortola, Maria
dc.contributor.authorAnibarro, Luis
dc.contributor.authorSuarez-Toste, Isabel
dc.contributor.authorMoga, Esther
dc.contributor.authorGude-Gonzalez, Maria J.
dc.contributor.authorNaves, Rodrigo
dc.contributor.authorKarsligil, Tekin
dc.contributor.authorMartin-Penaranda, Tania
dc.contributor.authorStevanovic, Goran
dc.contributor.authorTrigo, Matilde
dc.contributor.authorRubio, Veronica
dc.contributor.authorKaraoglan, Ilkay
dc.contributor.authorBayram, Nazan
dc.contributor.authorAlcaide, Fernando
dc.contributor.authorTebe, Cristian
dc.contributor.authorSantin, Miguel
dc.date.accessioned2025-01-20T22:03:07Z
dc.date.available2025-01-20T22:03:07Z
dc.date.issued2021
dc.description.abstractWe investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB2-TB1 value.0.6 IU.ml(-1) was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2>TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB2-TB1 result of >0.6 IU.ml(-1) and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 15.4%, and 17.7% with close, frequent, and sporadic contact had a TB2>TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB2-TB1 difference of.0.6 IU.ml(-1) was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection.
dc.description.abstractIMPORTANCE Contact tuberculosis tracing is essential to identify recently infected people, who therefore merit preventive treatment. However, there are no diagnostic tests that can determine whether the infection is a result of a recent exposure or not. It has been suggested that by using the QuantiFERON-TB gold plus, an interferon gamma (IFN-gamma) release assay, a difference in IFN-gamma production between the two antigen tubes (TB2 minus TB1) of.0.6 IU.ml(-1) could serve as a proxy marker for recent infection. In this large multinational study, infected individuals could not be classified according to the risk of recent exposure based on differences in IFN- g in TB1 and TB2 tubes that were higher than 0.6 IU.ml(-1). QuantiFERON-TB gold plus is not able to distinguish between recent and remotely acquired tuberculosis infection, and it should not be used for that purpose in contact tuberculosis tracing.
dc.description.funderDepartment of Clinical Sciences of the University of Barcelona
dc.fuente.origenWOS
dc.identifier.doi10.1128/Spectrum.00972-21
dc.identifier.issn2165-0497
dc.identifier.urihttps://doi.org/10.1128/Spectrum.00972-21
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94019
dc.identifier.wosidWOS:000736124700071
dc.issue.numero3
dc.language.isoen
dc.revistaMicrobiology spectrum
dc.rightsacceso restringido
dc.subjectQuantiFERON-TB gold plus
dc.subjectdiagnosis
dc.subjectlatent tuberculosis infection
dc.subjecttuberculosis-specific CD8 T cells
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIdentification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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