The histaminergic tuberomammillary nucleus is critical for motivated arousal

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dc.contributor.authorLuis Valdes, Jose
dc.contributor.authorSanchez, Cristian
dc.contributor.authorEugenia Riveros, Maria
dc.contributor.authorBlandina, Patrizio
dc.contributor.authorContreras, Marco
dc.contributor.authorFarias, Paula
dc.contributor.authorTorrealba, Fernando
dc.date.accessioned2024-01-10T13:43:50Z
dc.date.available2024-01-10T13:43:50Z
dc.date.issued2010
dc.description.abstractObtaining food, shelter or water, or finding a mating partner are examples of motivated behaviors, which are essential to preserve the species. The full expression of such behaviors requires a high but optimal arousal state. We tested the idea that tuberomammillary nucleus (TMN) histamine neurons are crucial to generate such motivated arousal, using a model of the appetitive phase of feeding behavior. Hungry rats enticed with food within a wire mesh box showed intense goal-directed motor activity aimed at opening the box, an increase in core temperature, a fast histamine release in the hypothalamus and an early increase in Fos immunoreactivity in TMN and cortical neurons. Enticing with stronger-tasting food induced stronger motor, temperature and Fos immunoreactivity brain responses than ordinary food pellets. TMN lesion greatly decreased all of those responses. We conclude that histamine neurons increase arousal and vegetative activity, allowing the normal unfolding of voluntary, goal-directed behavior such as obtaining food.
dc.description.funderFondecyt
dc.description.funderIniciativa Cientifica Milenio ICM
dc.description.funderMECESUP
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1460-9568.2010.07241.x
dc.identifier.eissn1460-9568
dc.identifier.issn0953-816X
dc.identifier.pubmedidMEDLINE:20529118
dc.identifier.urihttps://doi.org/10.1111/j.1460-9568.2010.07241.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78766
dc.identifier.wosidWOS:000278519800016
dc.information.autorucCiencias Biológicas;Contreras M;S/I;12276
dc.information.autorucCiencias Biológicas;Farías P;S/I;158183
dc.information.autorucCiencias Biológicas;Riveros ME;S/I;11111
dc.information.autorucCiencias Biológicas;Sánchez C;S/I;119504
dc.information.autorucCiencias Biológicas;Torrealba F;S/I;99202
dc.issue.numero11
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2085
dc.pagina.inicio2073
dc.publisherWILEY
dc.revistaEUROPEAN JOURNAL OF NEUROSCIENCE
dc.rightsacceso restringido
dc.subjectalertness
dc.subjecthistamine
dc.subjectmicrodialysis
dc.subjectmotivation
dc.subjectrat
dc.subjecttemperature
dc.subjectBROWN ADIPOSE-TISSUE
dc.subjectNEURONAL HISTAMINE
dc.subjectPREFRONTAL CORTEX
dc.subjectRAT HYPOTHALAMUS
dc.subjectBRAIN HISTAMINE
dc.subjectSLEEP
dc.subjectACTIVATION
dc.subjectBEHAVIOR
dc.subjectRELEASE
dc.subjectHETEROGENEITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe histaminergic tuberomammillary nucleus is critical for motivated arousal
dc.typeartículo
dc.volumen31
sipa.codpersvinculados12276
sipa.codpersvinculados158183
sipa.codpersvinculados11111
sipa.codpersvinculados119504
sipa.codpersvinculados99202
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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